|Name:||calcium channel, voltage-dependent, L type, alpha 1S subunit|
|PubMed (7916735):|| Gregg RG, Couch F, Hogan K, Powers PA. Assignment of the human gene for the alpha 1 subunit of the skeletal muscleDHP-sensitive Ca2+ channel (CACNL1A3) to chromosome 1q31-q32.Genomics. 1993 Jan;15(1):107-12. PMID: 7916735 [PubMed - indexed for MEDLINE]|
A human clone corresponding to the gene encoding the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (CACNL1A3) has been isolated and partially sequenced. Oligonucleotides based on this sequence were used in a polymerase chain reaction to amplify specifically the human gene in human-rodent somatic cell hybrids, allowing the assignment of CACNL1A3 to chromosome 1. A polymorphic dinucleotide repeat also was identified in the human clone and using PCR was typed on a subset of the CEPH families. Multipoint linkage analysis places the CACNL1A3 gene between D1S52 and D1S70, on chromosome 1q31-q32.