|Name:||potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1|
|PubMed (8781233):|| Kohler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J, AdelmanJP. Small-conductance, calcium-activated potassium channels from mammalian brain.Science. 1996 Sep 20;273(5282):1709-14. PMID: 8781233 [PubMed - indexed for MEDLINE]|
Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage-independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.
|PubMed (10516439):|| Litt M, LaMorticella D, Bond CT, Adelman JP. Gene structure and chromosome mapping of the human small-conductancecalcium-activated potassium channel SK1 gene (KCNN1).Cytogenet Cell Genet. 1999;86(1):70-3. PMID: 10516439 [PubMed - indexed for MEDLINE]|
Small-conductance, calcium-activated potassium channels contribute to the afterhyperpolarization in central neurons and other cell types. Because these channels regulate neuronal excitability, defects in their genes could cause excitability disorders. The human cDNA encoding one such channel, SK1 (KCNN1), was recently cloned. Here we describe the gene structure of KCNN1 and its localization by radiation hybrid mapping to chromosome 19p13.1.