TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.19.2
The ergothionine/organic cation porter, OctN1 (SLC22A4). Associated with rheumatoid arthritis (Barton et al., 2005).  Acetylcholine is a physiological substrate, and its transport could be involved in nonneuronal cholinergic functions (Pochini et al. 2013).  OCTN1 and OCTN2 are associated with several pathologies, such as inflammatory bowel disease, primary carnitine deficiency, diabetes, neurological disorders, and cancer. Transports TEA, and acetylcholine better than acetylcarnitine (Pochini et al. 2015).

Accession Number:
Protein Name:CDP-alcohol phosphatidyltransferase [Marinobacter excellens]
Length:245
Molecular Weight:
Species:Marinobacter excellens [218670]
Number of TMSs:8
Substrate Ergothionine, organic cations

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDSIRPATFQ IPAAVRELGW AALLLFFVLL SVHEWFSPPG WFGLLAILIF ATQGALILTR 
61:	WPARQNFGWA NRTTLLRSIL VVSLVAWAPF LPAADSSALW IYGVACLIAL ILDGVDGKVA 
121:	RATNSNSEFG ARFDMELDAL FIFGLCVATM AIGKAGPWVL MLALMRYAFL AASHFLTWLN 
181:	QPLPDSFRRK TVCVWQVVTL MIAILPPTPT GFAGTTLAMA LALLGWSFAL DVRWLYQRRH 
241:	YHEN