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1.A.1.19.3
Alkalinization-activated Ca2+-selective channel, Cation channel of sperm 1, CatSper1, required for male fertility and the hyperactivated motility of spermatozoa. These channels require auxiliary subunits, CatSper β, γ and δ for activity (Chung et al., 2011; Liu et al., 2007).

Accession Number:A2RTF1
Protein Name:Cation channel sperm-associated protein subunit beta
Length:1109
Molecular Weight:126108.00
Species: [10090]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: A2RTF1
eggNOG: roNOG05423
HEGENOM: HBG127339
RefSeq: NP_766611.2   
Entrez Gene ID: 271036   
KEGG: mmu:271036   

Gene Ontology

GO:0019861 C:flagellum
GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0030154 P:cell differentiation
GO:0007275 P:multicellular organismal development
GO:0007283 P:spermatogenesis

References (4)

[1] “CatSperbeta, a novel transmembrane protein in the CatSper channel complex.”  Liu J.et.al.   17478420
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein.”  Wang H.et.al.   19516020

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MESPLIYVML VLLNVFVFSS GVIHNKGKER TYFSCSGEGI LTGLHTIKLF LTMDNLKVRC 
61:	FFRNENQSPS KEILGLFTSG GLAPNMIITN STFYGGYYFK LTPFSNRLEW LIDIPRQNIT 
121:	VNTDIAAVEQ WMIKITMHEG LNIYDTEGTL LDLVREPILQ WNLGRVLTEM EVRDLYPEVN 
181:	DIKVTKSPCA NDVALIGFMM KPSSNGVFIG KTISGFWTYK ECIWHDLTEI IYAELKDEHQ 
241:	GLTVIDLVLT NHFLVILTSL GLYVSSDLRY PTTSQIKLSR AEFCGFERVD YIRGNLWYNE 
301:	KCFANRESFE VDYVTITFNR NRTLSESSSC FFSKEPFLHW LPCVFSTIKN EKSIPRVITF 
361:	LIDQETDSGI YLFNVQDTKE TYVTVAMLKD GKPSPRPKFP SFHFPSTFTL PLGMIFHPRS 
421:	HFLYVYGSQI WVSMDGGNTF EMLCNLFSHH VTKTSNSFYT SDIVFIVEDG RILTTKAGLT 
481:	TYSELGILKD AIFTLYYDQL GYIHKLTPEN FDAGSKLLGH GNSGSIFGKR PDLGFEAILV 
541:	PQYISTNEMY FFAHVPLTMP TNIQWKKRFK TIHLGKTIEF SKTGLANIKN VYMHKTEPVG 
601:	FQTSIHTEII VPFGIENSKD SPCLLSDLEI TYSGKLYYTI KLLSKNPLHE LKSTDVEKSV 
661:	LIPGYSSFLI MNITDKWTAS ALATMPQAIK SNLKFLTGSW FLYNFGTAGG RKWSISTRQC 
721:	NYWIQQDSLD FMSLNLVKYI DVGNTIDFQF KIIPKAMSTF PIPPVSMVVG NPGLVEVKTQ 
781:	GVFDLNENYY LDIHVSGRFF QKGSTSIALV LWEGSSKCYA ITLLPTIKSS CSYLRTMHHT 
841:	PGRHIPPEDW ISGVHKDSQG FNMIKTLPIN YRPPSHMGIS IPLTDNFYHA DPSKPIPRNQ 
901:	FHKSKETGKY KQCANVTSRA MCNCSEHQKF SHAVAFSDCK EKVHRFKFPV TQYPVVLEIF 
961:	NERDKISAEP PYLVTMTEVN MRKNWQLKHN EPENVKKMKH YLEPLLKTPV YNPLGLNLTI 
1021:	QGSELFHFKV SVVPGVSFCE LSEEFQIYVD EVPLPFPGHA LIAVATSVVL GVLIFIAFVF 
1081:	QLRNIHPLKA LKKSIRGNPG LTSSTTVSS