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3.A.1.12.13
High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7)

Accession Number:A9CI32
Protein Name:ABC transporter, nucleotide binding/ATPase protein (Proline/glycine betaine)
Length:348
Molecular Weight:37280.00
Species:Agrobacterium tumefaciens (strain C58 / ATCC 33970) [176299]
Substrate Choline

Cross database links:

eggNOG: COG4175
HEGENOM: HBG758042
Entrez Gene ID: 1134317   
Pfam: PF00005   
KEGG: atu:Atu2279   

Gene Ontology

GO:0055052 C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0015220 F:choline transmembrane transporter activity

References (2)

[1] “The genome of the natural genetic engineer Agrobacterium tumefaciens C58.”  Wood D.W.et.al.   11743193
[2] “Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.”  Goodner B.et.al.   11743194

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDAIIFGNV DIVFGDRPDA ALALIDKGST RDEINAQTGL VLGVANASLS VSEGEILVLM 
61:	GLSGSGKSTL VRAVNGLAPV VRGSVSVKTK SGYVDPYRCP AKALRDLRMH TVSMVFQQFG 
121:	LLPWRNVADN VGFGLELSGV PEAERKRMVA EQLELVNLSA WADRKVGELS GGMQQRVGLA 
181:	RAFATGAPIL LMDEPFSALD PLIRSRLQDE LLEFQSRLKK TILFVSHDLD EAFRIGNRIA 
241:	MMEGGHIIQC GTPQQIVRQP ATPYVADFVQ NMNPISMLTA ADVMKRGVDE RSGRLTVAAT 
301:	ALPSSPLIDI LDALSKHAGA IGVVDNGAII GTISADEVVA GLTRHRKK