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3.A.1.106.3
The dimeric multidrug resistance exporter, ABC1/2 (exports the peptide antimicrobials, nisin and polymyxin; (Margolles et al., 2006) (both ABC1 and ABC2 also show striking similarity to family 3.A.1.117).

Accession Number:B3DPC5
Protein Name:MdlB4
Length:636
Molecular Weight:70328.00
Species:Bifidobacterium longum DJO10A [205913]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate Nisin, Polymyxin

Cross database links:

HEGENOM: HBG758042
RefSeq: YP_001955482.1   
Entrez Gene ID: 6364354   
Pfam: PF00664    PF00005   
KEGG: blj:BLD_1539   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (1)

[1] “Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth.”  Lee J.H.et.al.   18505588

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MYVDPGINTS ASNLKWVLPY CKPDLPRVVG ALLLFIANNT MALTIPILSG IIVDRVIVGG 
61:	HADELPRLCG LMILMTIIRV GARYGYQMWM ERFGQNSVYR LVSDEYEKLH ELDFTYFNHT 
121:	RTGDIMSRLT SDTDAIRHCL SWVSYQIADC VVMFVGALCV MFAIDWRLAL VLACVTPFIF 
181:	VLTRGLSTHA HPLFFAIRNS LASLNSMVEE NIEGNRVVKA FVREPYETEK FDEHNDDYMQ 
241:	CNMALAYNSR KYMPWLDGLG FSLQLITLGL GGFLVIKGYM TLGNLVSFNS FLWMIDGPVR 
301:	QSGWLINDWQ RFNASCIKIR KLLTEQPRIV EKPDAVEAVK QAVTIVEQVK HDDEATGATG 
361:	APVASGTSGA QQSTERKSCP LHIKGDIRFD HVSFAFPDDP ETPILKDLDF TVPAGSKLGI 
421:	LGETGAGKST LVSLISRFYD PTVGHVLIDG IDARDWPLAT LRSQVCIVAQ DTFLFSDTIG 
481:	GNIGFGASGD SDDRYIQKMA QIAGADNFIR SMPQGYDTVV GERGVGLSGG QKQRLSLARA 
541:	LADNPSILIM DDTTSAVDME TEAEIQKHLK EMDGGKTIVA IAHRISSVKD SDLILVLEHG 
601:	RIVERGTHAE LVAAHGRYWD IYHKQLGLQS GVAQGF