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4.A.2.1.5
The mannitol porter (MtlA) (mannitol-1-P forming), MtlAF.  The system is encoded by the mannitol catabolic operon, mtlAFD, and is regulated by the transcription factor, MtlR (Joyet et al. 2015). MtlR contains an N-terminal helix-turn-helix motif followed by an Mga-like domain, two PTS regulatory domains (PRDs), an Enzyme IIBGat-like domain and an Enzyme IIAMtl-like domain, the last four of which can be phosphorylated by the PTS.  MtlR proteins are also found in Geobacillus stearothermophilus and Lactobacillus casei, but the mechanisms of their action are different (Joyet et al. 2015).  The dephosphorlyated form of the protein activates transcription (Heravi and Altenbuchner 2014).

Accession Number:C0H3V2
Protein Name:Mannitol-specific phosphotransferase enzyme IIA component
Length:143
Molecular Weight:15747.00
Species:Bacillus subtilis (strain 168) [224308]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate mannitol

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FASTA formatted sequence
1:	MQVLAKENIK LNQTVSSKEE AIKLAGQTLI DNGYVTEDYI SKMFEREETS STFMGNFIAI 
61:	PHGTEEAKSE VLHSGISIIQ IPEGVEYGEG NTAKVVFGIA GKNNEHLDIL SNIAIICSEE 
121:	ENIERLISAK SEEDLIAIFN EVN