The mannitol porter (MtlA) (mannitol-1-P forming), MtlAF. The system is encoded by the mannitol catabolic operon, mtlAFD, and is regulated by the transcription factor, MtlR (Joyet et al. 2015). MtlR contains an N-terminal helix-turn-helix motif followed by an Mga-like domain, two PTS regulatory domains (PRDs), an Enzyme IIBGat-like domain and an Enzyme IIAMtl-like domain, the last four of which can be phosphorylated by the PTS. MtlR proteins are also found in Geobacillus stearothermophilus and Lactobacillus casei, but the mechanisms of their action are different (Joyet et al. 2015). The dephosphorlyated form of the protein activates transcription (Heravi and Altenbuchner 2014).
|Protein Name:||Mannitol-specific phosphotransferase enzyme IIA component|
|Species:||Bacillus subtilis (strain 168)  |
|Location1 / Topology2 / Orientation3:
1: MQVLAKENIK LNQTVSSKEE AIKLAGQTLI DNGYVTEDYI SKMFEREETS STFMGNFIAI
61: PHGTEEAKSE VLHSGISIIQ IPEGVEYGEG NTAKVVFGIA GKNNEHLDIL SNIAIICSEE
121: ENIERLISAK SEEDLIAIFN EVN