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3.A.1.25.7
The riboflavin uptake system, BioMNY.  BioM, EtcA, ATPase, 234 aas;  BioN, EtcT, 190 aas, 5 TMSs; BioY, EtcS, 210 aas, 5 TMSs BioY can also function as a secondary carrier and is therefore listed separately under TC# 2.A.88.1.3.  ATP-dependent conformational changes drive substrate capture and release when BioMNY are together in a complex (Finkenwirth et al. 2015).

Accession Number:D5ARG8
Protein Name:Biotin transporter BioY
Length:190
Molecular Weight:19306.00
Species:Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) [272942]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate riboflavin

Cross database links:

HEGENOM: HOG000246867
Entrez Gene ID: 9006065   
Pfam: PF02632   
KEGG: rcp:RCAP_rcc032   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (2)

[1] “Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003.”  Strnad H.et.al.   20418398
[2] “Biotin uptake in prokaryotes by solute transporters with an optional ATP-binding cassette-containing module.”  Hebbeln P.et.al.   17301237

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERNVTLIGL FAALIVALGF VPAIPLGFGV PITLQSLGVM LAGAVLGSWR GALAVLLVQA 
61:	LVAIGLPVLA GGRGGLGIFV GPTAGFLIGW LPAAFVTGLI VERLRRVPVA LAAGIGATLG 
121:	GIIIMYALGI LGFWLVKNAG LKPEDAPISL WAATAIMAPF IPGDLVKVVV TGLVARTIAQ 
181:	YRPSALLARG