TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.1.48
The lacto-N-biose I (LNB; Gal β-1,3-GlcNAc)/galacto-N-biose (GNB; Gal β-1,3-GalNAc) transporter.  The solute-binding protein crystallizes only in the presence of LNB or GNB, and it was therefore named GNB/LNB-binding protein (GL-BP) (Wada et al. 2007; Suzuki et al. 2008; Asakuma et al. 2011). Isothermal titration calorimetry measurements revealed that GL-BP specifically binds LNB and GNB with K(d) values of 0.087 and 0.010 μM, respectively, and the binding process is enthalpy-driven. The crystal structures of GL-BP complexed with LNB, GNB, and lacto-N-tetraose (Galbeta1-3GlcNAcbeta1Suzuki et al. 2008; Asakuma et al. 2011). Isothermal titration calorimetry measurements revealed that GL-BP specifically binds LNB and GNB with K(d) values of 0.087 and 0.010 μM, respectively, and the binding process is enthalpy-driven. The crystal structures of GL-BP complexed with LNB, GNB, and lacto-N-tetraose (Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc) were determined.  The MalF and MalG membrahe proteinAsakuma et al. 2011). Isothermal titration calorimetry measurements revealed that GL-BP specifically binds LNB and GNB with K(d) values of 0.087 and 0.010 μM, respectively, and the binding process is enthalpy-driven. The crystal structures of GL-BP complexed with LNB, GNB, and lacto-N-tetraose (Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc) were determined.  The MalF and MalG membrahe proteins are encoded adjacent to the gene for GL-BP, but the ATPase was not identified.

Accession Number:D6ZW62
Protein Name:Permease of ABC transporter for sugars
Length:316
Molecular Weight:34690.00
Species:Bifidobacterium longum subsp. longum (strain JDM301) [759350]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Lacto-N-biose

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSSATVEERA RKKAERKLEK QRQAAQHDLP RSMRPSAAVK TLTVVLLVLV LIYFLFPIYW 
61:	AIIASTKTPA QMTGSNGMWF AVPLDQLPNA IATNYSKLLG WTRGNFWRWV LNSLIYSGVS 
121:	ALIGTIVSVM AGYATAKFNF RGKNAAIGII MACMLMPSAL LTIPMYSIFH TLHLTNTMLS 
181:	IIIPCCVSPF GFFLGRTYAQ SSVPDELLEA ARIDGASEAR IFFTIVLRLL APAMVTIFLF 
241:	LFVATWNNFL LPLMMVSSDT LKPVTLGLYG MVSLATFTDR GALMMGALLG VLPVIVLFLG 
301:	LQRYWQSGLA AGAVKG