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3.A.18.1.1
The nuclear mRNA Export Complex (mRNA-E also called TREX) (including the exon junction complex) [TAP+p15 interact as a complex with the nuclear pore to facilitate mRNA transport to the cytoplasm] (Nojimma et al. 2007; Cheng et al., 2006)

Accession Number:O00422
Protein Name:Histone deacetylase complex subunit SAP18
Length:153
Molecular Weight:17561.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Nucleus1
Substrate mRNA

Cross database links:

Genevestigator: O00422
eggNOG: prNOG05651
HEGENOM: HBG745731
RefSeq: NP_005861.2   
Entrez Gene ID: 10284   
Pfam: PF06487   
OMIM: 602949  gene
KEGG: hsa:10284   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0000118 C:histone deacetylase complex
GO:0003714 F:transcription corepressor activity
GO:0006357 P:regulation of transcription from RNA polyme...
GO:0006350 P:transcription

References (6)

[1] “Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.”  Zhang Y.et.al.   9150135
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and analysis of human chromosome 13.”  Dunham A.et.al.   15057823
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.”  Tange T.O.et.al.   16314458
[6] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
Structure:
2HDE     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT 
61:	WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM 
121:	TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY