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1.A.6.2.2
Touch-responsive mechanosensitive degenerin channel complex (Mec-4/Mec-10 form the cation/Ca2+-permeable channel; Mec-2 and Mec-6 regulate) (Bianchi, 2007; Chelur et al., 2002; ). Mec-6 is a chaparone protein required for functional insertion (Matthewman et al. 2018). Mec-10 plays a role in the response to mechanical forces such as laminar shear stress (Shi et al. 2016). MEC-4 or MEC-10 mutants that alter the channel's LSS response are primarily clustered between the degenerin site and the selectivity filter, a region that likely forms the narrowest portion of the channel pore (Shi et al. 2018). TMS2 forms the Ca2+ channel of Mec-4.  A C-terminal domain affects trafficking of a neuronally expressed DEG/ENaC. Neuronal swelling occurs prior to commitment to necrotic death (Royal et al. 2005).

Accession Number:O01811
Protein Name:Mechanosensory abnormality protein 6
Length:377
Molecular Weight:42491.00
Species: [6239]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: meNOG12414
HEGENOM: HBG378259
RefSeq: NP_491925.2   
Entrez Gene ID: 172389   
Pfam: PF01731   
KEGG: cel:W02D3.3   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0004064 F:arylesterase activity
GO:0005272 F:sodium channel activity
GO:0008219 P:cell death
GO:0006813 P:potassium ion transport
GO:0006814 P:sodium ion transport

References (2)

[1] “The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel.”  Chelur D.S.et.al.   12478294
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGLQSAAAHF INRFIIWITI FMVACFLLRL LVVLDLNKRV YNHTPGPCRV LTDNYKGTAG 
61:	MTYVESQKRV YITLGYGRAH DLKTKTGIAF YKTNRTDGRS QQEMYDLIEM TINWNGYEYK 
121:	KEFIPTGIDS YSSSNGRVLL YVINAHPNHQ CIHFFQIVES SKLNHRKAIC DPSFSSLQDI 
181:	AVVGPDRLFV TNMAAFGRGW AQILEFSLQT GQGAVYYYDG SKLSTAASSL IAPTGIGYDA 
241:	KRRILYVGSM IRESIFAYKV AKDTTLELLY EMMLLTSPIG VFVESKTGDI WIAAHPVIHE 
301:	SAWHYTHPEN QNIHSPSQIL RIRIQEEGNS WVTTEPYAND GATISASSSV VFTDEQMLIG 
361:	SSFGRLLHCD LTHSYIT