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3.A.1.12.4
Uptake system for choline, L-carnitine, D-carnitine, glycine betaine, proline betaine, crotonobetaine, γ-butyrobetaine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and choline-O-sulfate

Accession Number:O32243
Protein Name:OPCC aka OpuCC
Length:303
Molecular Weight:33957.00
Species:Bacillus subtilis [1423]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Lipid-anchor2
Substrate Choline, Carnitine, Glycine betaine, Proline betaine, Crotonobetaine, Gamma-butyrobetaine, Dimethylsulfonioacetate, Dimethylsulfoniopropionate, Ectoine, Choline-O-sulfate

Cross database links:

HEGENOM: HBG694086
RefSeq: NP_391261.1   
Entrez Gene ID: 936248   
Pfam: PF04069   
KEGG: bsu:BSU33810   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (2)

[1] “Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis.”  Kappes R.M.et.al.   10216873
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
Structure:
3PPN   3PPO   3PPP   3PPQ   3PPR     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MTKIKWLGAF ALVFVMLLGG CSLPGLGGAS DDTIKIGAQS MTESEIVANM IAQLIEHDTD 
61:	LNTALVKNLG SNYVQHQAML GGDIDISATR YSGTDLTSTL GKEAEKDPKK ALNIVQNEFQ 
121:	KRFSYKWFDS YGFDNTYAFT VTKKFAEKEH INTVSDLKKN ASQYKLGVDN AWLKRKGDGY 
181:	KGFVSTYGFE FGTTYPMQIG LVYDAVKNGK MDAVLAYSTD GRIKAYDLKI LKDDKRFFPP 
241:	YDCSPVIPEK VLKEHPELEG VINKLIGQID TETMQELNYE VDGKLKEPSV VAKEFLEKHH 
301:	YFD