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3.A.1.15.3
Zinc (Zn2+) porter, AdcABC/AII

Accession Number:O33704
Protein Name:AdcB aka SP2170
Length:268
Molecular Weight:28890.00
Species:Streptococcus pneumoniae [1313]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

HEGENOM: HBG733179
RefSeq: NP_346584.1   
Entrez Gene ID: 930196   
Pfam: PF00950   
KEGG: spn:SP_2170   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0006810 P:transport

References (3)

[1] “The adc locus, which affects competence for genetic transformation in Streptococcus pneumoniae, encodes an ABC transporter with a putative lipoprotein homologous to a family of streptococcal adhesins.”  Dintilhac A.et.al.   9765793
[2] “Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases.”  Dintilhac A.et.al.   9379902
[3] “Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.”  Tettelin H.et.al.   11463916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSLLSYDFI QRAFLAVIAM SLFSPVLGTF LILRRQSLMS DTLSHVSLSG VAFGLVLGIS 
61:	PTVSTIAIVL IAAVFLEYLR TVYKSFMEIG TAILMSTGLA VSLIVMSKGK SSSSMSLDQY 
121:	LFGSIVTISE EQVISLFVIA AVVLILTFLF LRPMYILTFD EDTAFVDGLP VRTMSILFNM 
181:	VTGVAIALMI PAAGALLVST IMVLPASIAL RLGKNFKSVM LLASAIGFLG MVAGLYISYY 
241:	AETPASASIT IIFVTVFILI SLVRRFIK