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3.A.1.30.1
The putative thiamin precursor uptake transporter, YkoEDC (Rodionov et al., 2009) (E is most similar to 3.A.1.4.3; D is most similar to 3.A.1.26.2; C is most similar to 3.A.1.23.2).

Accession Number:O34572
Protein Name:Putative HMP/thiamine permease protein ykoC
Length:254
Molecular Weight:28042.00
Species:Bacillus subtilis [1423]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Thiamin precursors

Cross database links:

HEGENOM: HBG337947
RefSeq: NP_389204.1   
Entrez Gene ID: 939836   
Pfam: PF02361   
BioCyc: SUBTI:BSU13210-MONOMER   
KEGG: bsu:BSU13210   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015087 F:cobalt ion transmembrane transporter activity
GO:0009236 P:cobalamin biosynthetic process
GO:0006824 P:cobalt ion transport

References (3)

[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[2] “Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms.”  Rodionov D.A.et.al.   12376536
[3] “Isolation and characterization of new thiamine-deregulated mutants of Bacillus subtilis.”  Schyns G.et.al.   16291685

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKQPLHLINP TVKAAAVFCC VVMLSFIYNP YTPACFYIII VAGVLLAAGI PLKKWLLFTI 
61:	PFLILAFGCV WTAAVFGKVP TTPDNFLFQA GPISINSDNV SVGISLGFRI LCFSALSMMF 
121:	VFTTDPILFM LSLVQQCRLS PKLAYGVIAG FRFLPLLKDE VQLIQQAHKI RGGAAESGII 
181:	NKISALKRYT IPLLASAIRK AERTALAMES KGFTGSRNRT YYRTLSVNRR DWVFFCLVLL 
241:	LFAGSFLVSL CFAS