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3.A.1.30.1
The putative thiamin precursor uptake transporter, YkoEDC (Rodionov et al., 2009) (E is most similar to 3.A.1.4.3; D is most similar to 3.A.1.26.2; C is most similar to 3.A.1.23.2).

Accession Number:O34738
Protein Name:Putative HMP/thiamine permease protein ykoE
Length:199
Molecular Weight:21224.00
Species:Bacillus subtilis [1423]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Thiamin precursors

Cross database links:

HEGENOM: HBG516202
RefSeq: NP_389206.2   
Entrez Gene ID: 939829   
Pfam: PF09819   
BioCyc: SUBTI:BSU13230-MONOMER   
KEGG: bsu:BSU13230   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (4)

[1] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[2] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706
[3] “Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms.”  Rodionov D.A.et.al.   12376536
[4] “Isolation and characterization of new thiamine-deregulated mutants of Bacillus subtilis.”  Schyns G.et.al.   16291685
Structure:
5edl     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKSWKVKEIV IMSVISIVFA VVYLLFTHFG NVLAGMFGPI AYEPIYGIWF IVSVIAAYMI 
61:	RKPGAALVSE IIAALVECLL GNPSGPMVIV IGIVQGLGAE AVFLATRWKA YSLPVLMLAG 
121:	MGSSVASFIY DLFVSGYAAY SPGYLLIMLV IRLISGALLA GLLGKAVSDS LAYTGVLNGM 
181:	ALGKELKKKR KRASEHASL