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3.A.1.12.4
Uptake system for choline, L-carnitine, D-carnitine, glycine betaine, proline betaine, crotonobetaine, γ-butyrobetaine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and choline-O-sulfate

Accession Number:O34878
Protein Name:OPCB aka OpuCB
Length:217
Molecular Weight:23149.00
Species:Bacillus subtilis [1423]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Choline, Carnitine, Glycine betaine, Proline betaine, Crotonobetaine, Gamma-butyrobetaine, Dimethylsulfonioacetate, Dimethylsulfoniopropionate, Ectoine, Choline-O-sulfate

Cross database links:

HEGENOM: HBG592565
RefSeq: NP_391262.1   
Entrez Gene ID: 937105   
Pfam: PF00528   
KEGG: bsu:BSU33820   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (2)

[1] “Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis.”  Kappes R.M.et.al.   10216873
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNQMMTFLQT NGGELLYKTG EHLYISLIAV VLGIIVAVPL GVALTRMKKG AGAVIGFVNI 
61:	VQTLPSLAIL AFFIPLLGVG KVPAIVALFF YSVLPILRNT YTGIKGVNKN LLESGKGIGM 
121:	TGWEQIRLVE IPLAIPIIMA GIRTSTIYLI GWATLASFIG GGGLGDYIFI GLNLYQPEYI 
181:	IGGAVPVTIL AIIIDYVLAV TERKVTPKGL QGMKEVS