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3.A.1.3.13
Uptake system for L-cystine (Km=2.5 μM), L-cystathionine, L-djenkolate ( 2-amino-3-[(2-amino-3-hydroxy-3-oxopropyl)sulfanylmethylsulfanyl] propanoic acid), and S-methyl-L-cysteine (Burguière et al., 2004, Burguière et al., 2005)

Accession Number:O34931
Protein Name:TcyM (YtmM)
Length:235
Molecular Weight:25593.00
Species:Bacillus subtilis [1423]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Djenkolate, Cystathionine, S-methylcysteine

Cross database links:

HEGENOM: HBG704821
RefSeq: NP_390813.1   
Entrez Gene ID: 935938   
Pfam: PF00528   
KEGG: bsu:BSU29350   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (4)

[1] “Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region.”  Lapidus A.et.al.   9387221
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Global expression profile of Bacillus subtilis grown in the presence of sulfate or methionine.”  Auger S.et.al.   12193636
[4] “Three different systems participate in L-cystine uptake in Bacillus subtilis.”  Burguiere P.et.al.   15262924

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQFDFPFIVS AMKEMVKTIP LTLMMAVLPI VFGFLVALGN IIVRIFRIKG LVACSRFYVS 
61:	FFRSTPAILH IMLIYLGIPP VADQVSSFFH LGWSANEIPV SMFVIMALSL TAGAYLTEII 
121:	RSGILAMDTG QVEAAYSIGL TYSQTFRRVI LPQALKVSIP NFTNLGIGFL HTTSIAAIVA 
181:	VPEITGTATI VASDNYAFLE AFIGAAIIYW VLTLILESAN GVLERKAARF QGGTL