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3.A.1.12.4
Uptake system for choline, L-carnitine, D-carnitine, glycine betaine, proline betaine, crotonobetaine, γ-butyrobetaine, dimethylsulfonioacetate, dimethylsulfoniopropionate, ectoine and choline-O-sulfate

Accession Number:O34992
Protein Name:OPCA aka OpuCA
Length:380
Molecular Weight:43247.00
Species:Bacillus subtilis [1423]
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Choline, Carnitine, Glycine betaine, Proline betaine, Crotonobetaine, Gamma-butyrobetaine, Dimethylsulfonioacetate, Dimethylsulfoniopropionate, Ectoine, Choline-O-sulfate

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_391263.1   
Entrez Gene ID: 937136   
Pfam: PF00005    PF00571   
KEGG: bsu:BSU33830   

Gene Ontology

GO:0016020 C:membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0006865 P:amino acid transport
GO:0008152 P:metabolic process

References (2)

[1] “Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis.”  Kappes R.M.et.al.   10216873
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLKLEQVSKV YKGGKKAVNS IDLDIAKGEF ICFIGPSGCG KTTTMKMINR LIEPSSGRIF 
61:	IDGENIMEQD PVELRRKIGY VIQQIGLFPH MTIQQNISLV PKLLKWPEEK RKERARELLK 
121:	LVDMGPEYLD RYPHELSGGQ QQRIGVLRAL AAEPPLILMD EPFGALDPIT RDSLQEEFKK 
181:	LQRTLNKTIV FVTHDMDEAI KLADRIVILK AGEIVQVGTP DEILRNPANE FVEEFIGKER 
241:	LIQSRPDIER VEQMMNRTPV TVSADKTLSQ AIQLMREKRV DSLLVVDRQN VLKGYVDVEM 
301:	IDQNRKKASI VGDVYRSDIY TVQKGALLRD TVRKILKQGI KYVPVVDEQN HLAGIVTRAS 
361:	LVDIVYDSIW GDEENQLMTI