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1.C.36.1.1
IIITCP protein complex EspB/EspD. The topology of and EspD interaction sites in EspB have been defined (Luo and Donnenberg, 2011).  EspD inserts into the membrane with its two helical hairpins traversing the membrane with the N- and C-termini on the extraluminal surface, forming 2.5 diameter pores (Chatterjee et al. 2015).

Accession Number:O69413
Protein Name:EspD
Length:374
Molecular Weight:39093.00
Species:Escherichia coli [562]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

References (1)

[1] “Pas, a novel protein required for protein secretion and attaching and effacing activities of enterohemorrhagic Escherichia coli.”  Kresse A.U.et.al.   9721271

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLNVNNDTLS VTSGVNTASG TSGITQSETG LSLDLQLVKS MNSSAGWTES SPLPTPPAGH 
61:	SLVTPSAAED VLSKLFGGIS GEVTSRTEEA EPQRTSYPYL SQVNTVDPQQ MMMMVTLLSL 
121:	DTSAQKVSSL KNSNEIYMDG QTKALENKTQ EYKKQLEEQQ KAEEKSQKSK IVGQVFGWLG 
181:	VALTAVAAVF NPALWAVVAI GATAMALQTA VDVMGENAPQ GLKTAAQVFG GISMAASILT 
241:	AGVGGVSSLL PKFGNVANKI GSSVVKVVEK AAEALVKNVF AKISTVAEGV TNGIRSAGTT 
301:	ALNNEAAQLQ MLSQLAAFAV QNLTRQSESL GESAKLELDK AASELQNQAS YLQSVSQLMS 
361:	DSARVNSRIV SGRI