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2.A.6.2.24
The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)

Accession Number:O87935
Protein Name:AmrA
Length:399
Molecular Weight:42479.00
Species:Burkholderia pseudomallei (Pseudomonas pseudomallei) [28450]
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Streptomycin, Gentamycin, Neomycin, Tobramycin, Kanamycin, Spectinomycin, erythromycin, Clarithromycin, Lincosamide, Clindamycin

Cross database links:

Pfam: PF00529   

Gene Ontology

GO:0016020 C:membrane
GO:0008565 F:protein transporter activity
GO:0009306 P:protein secretion

References (1)

[1] “Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.”  Moore R.A.et.al.   10049252

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKYEWARTRR LSAALAVAAF VAAGCGKHES EHDAAAPREA SVVTVKKTSV PLSVELPGRL 
61:	DAYRQAEVRA RVAGIVTART YEEGQEVKRG AVLFRIDPAP FKAARDAAAG ALEKAQAAHL 
121:	AALDKRRRYD ELVRDRAVSE RDHTEALADE RQAKAAVASA RAELARAQLQ LDYATVTAPI 
181:	DGRARRALVT EGALVGQDQA TPLTTVEQLD PIYVNFSQPA ADVESLRRAV KSGRAAGIAQ 
241:	QDVEVTLVRP DGSTYARKGK LLFADLAVDP STDTVAMRAL FPNPERELLP GAYVRIALDR 
301:	AVARDAILVP RDALLRTADS ATVKVVGQNG KIRDVTVEAA QMKGRDWIVT RGLAGGERVV 
361:	VVDAAQFEAG TTVKALERGA AAQPASGAAA ASAPGRRST