TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.6.2.24
The multidrug (aminoglycosides (e.g., streptomycin, gentamycin, neomycin, tobramycin, kanamycin and spectinomycin) and macrolides (e.g., erythromycin and clarithromycin, but not lincosamide and clindamycin)) efflux pump, AmrAB-OprA (Moore et al., 1999)

Accession Number:O87936
Protein Name:AmrB
Length:1043
Molecular Weight:111217.00
Species:Burkholderia pseudomallei (Pseudomonas pseudomallei) [28450]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Streptomycin, Gentamycin, Neomycin, Tobramycin, Kanamycin, Spectinomycin, erythromycin, Clarithromycin, Lincosamide, Clindamycin

Cross database links:

Pfam: PF00873   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.”  Moore R.A.et.al.   10049252

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MARFFIDRPV FAWVISLFIM LGGIFAIRAL PVAQYPDIAP PVVSLYATYP GASAQVVEES 
61:	VTAVIEREMN GVPGLLYTSA TSSAGQASLS LTFKQGVSAD LAAVDVQNRL KIVEARLPEP 
121:	VRRDGISIEK AADNAQIIVS LTSEDGRISG VELGEYASAN VLQALRRVEG VGKVQFWGAE 
181:	YAMRIWPDPV KMAALGLTAS DIASAVRAHN ARVTIGDVGR SAVPDSAPIA ATVLADAPLT 
241:	TPDAFGAIAL RARADGSTLY LRDVARIEFG GNDYNYPSFV NGKTATGMGI KLAPGSNAVA 
301:	TEKRVRATME ELAKFFPPGV KYQIPYETAS FVRVSMSKVV TTLVEAGVLV FAVMFLFMQN 
361:	FRATLIPTLV VPVALLGTFG AMLAAGFSIN VLTMFGMVLA IGILVDDAIV VVENVERLMV 
421:	EEKLPPYEAT VKAMKQISGA IVGITVVLTS VFVPMAFFGG AVGNIYRQFA FALAVSIGFS 
481:	AFLALSLTPA LCATLLKPVA DDHHEKDGFF GWFNRFVARS THRYTRRVGR VLERPLRWLV 
541:	VYGALTAAAA LLITKLPAAF LPDEDQGNFM VMVIRPQGTP LAETMQSVRR VEEYVRTHSP 
601:	SAYTFALGGY NLYGEGPNGG MIFVTMKDWK ERKRARDQVQ AIIAEINAHF AGTPNTMVFA 
661:	INMPALPDLG LTGGFDFRLQ DRGGLGYGAF VAAREKLLAE GRKDPVLTDL MFAGTQDAPQ 
721:	LKLDIDRAKA SALGVSMEEI NATLAVMFGS DYIGDFMHGS QVRRVIVQAD GRHRLDAADV 
781:	TKLRVRNAKG EMVPLAAFAT LHWTMGPPQL TRYNGFPSFT INGAASAGHS SGEAMAAIER 
841:	IASTLPAGTG YAWSGQSYEE RLSGAQAPML FALSVLVVFL ALAALYESWS IPFAVMLVVP 
901:	LGVIGAVAGV TLRGMPNDIY FKVGLIATIG LSAKNAILIV EVAKDLVAQR MSLADAALEA 
961:	ARLRLRPIVM TSLAFGVGVL PLAFATGAAS GAQIAIGTGV LGGVISATLF AIFLVPLFFV 
1021:	CVGRVFDVVP RRPGGAQAAL EAK