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3.A.1.3.1
Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium  ligands only one substrate molecule in between its two transmembrane subunits, HisM and HisQ (Heuveling et al. 2019).

Accession Number:P02915
Protein Name:HisP aka STM2351
Length:258
Molecular Weight:28771.00
Species:Salmonella typhimurium [90371]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2
Substrate Ornithine, Arginine, lysine, Histidine

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_461293.1   
Entrez Gene ID: 1253873   
Pfam: PF00005   
BioCyc: STYP99287:STM2351-MONOMER   
KEGG: stm:STM2351   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0006865 P:amino acid transport

References (3)

[1] “Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium.”  Higgins C.F.et.al.   7050725
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
[3] “Crystal structure of the ATP-binding subunit of an ABC transporter.”  Hung L.W.et.al.   9872322
Structure:
1B0U     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMSENKLHVI DLHKRYGGHE VLKGVSLQAR AGDVISIIGS SGSGKSTFLR CINFLEKPSE 
61:	GAIIVNGQNI NLVRDKDGQL KVADKNQLRL LRTRLTMVFQ HFNLWSHMTV LENVMEAPIQ 
121:	VLGLSKHDAR ERALKYLAKV GIDERAQGKY PVHLSGGQQQ RVSIARALAM EPDVLLFDEP 
181:	TSALDPELVG EVLRIMQQLA EEGKTMVVVT HEMGFARHVS SHVIFLHQGK IEEEGDPEQV 
241:	FGNPQSPRLQ QFLKGSLK