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9.A.48.1.1
The Unconventional Protein Secretion System, UPSS (Giuliani et al., 2011).  Secretes FGF1 and Epimorphin (syntaxin 2) (Hirai et al. 2007)

Accession Number:P07356
Protein Name:Anxa2 aka Annexin A2
Length:339
Molecular Weight:38676.00
Species:Mus musculus (Mouse) [10090]
Location1 / Topology2 / Orientation3: Secreted1
Substrate proteins

Cross database links:

Genevestigator: P07356
eggNOG: roNOG14532
HEGENOM: HBG745057
RefSeq: NP_031611.1   
Entrez Gene ID: 12306   
Pfam: PF00191   
KEGG: mmu:12306   

Gene Ontology

GO:0005604 C:basement membrane
GO:0005769 C:early endosome
GO:0042470 C:melanosome
GO:0042383 C:sarcolemma
GO:0005509 F:calcium ion binding
GO:0005544 F:calcium-dependent phospholipid binding
GO:0008092 F:cytoskeletal protein binding
GO:0004859 F:phospholipase inhibitor activity
GO:0001525 P:angiogenesis
GO:0030199 P:collagen fibril organization
GO:0042730 P:fibrinolysis

References (6)

[1] “The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats.”  Saris C.J.M.et.al.   3013423
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene.”  Amiguet P.et.al.   2138915
[4] “Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons.”  Fey M.F.et.al.   8634333
[5] “Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.”  Lennon N.J.et.al.   14506282
[6] “Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.”  Wolf-Yadlin A.et.al.   17389395
Structure:
4HRE     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG VDEVTIVNIL 
61:	TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 
121:	LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 
181:	EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 
241:	LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 
301:	LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD