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3.A.4.1.1
Arsenical resistance efflux pump (ATP-dependent)

Accession Number:P08690
Protein Name:Arsenical pump-driving ATPase ARA1 aka ArsA
Length:583
Molecular Weight:63188.00
Species:Escherichia coli [562]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Arsenical

Cross database links:

DIP: DIP-16995N
Drugbank: Drugbank Link   

Gene Ontology

GO:0015446 F:arsenite transmembrane-transporting ATPase ...
GO:0005524 F:ATP binding
GO:0006875 P:cellular metal ion homeostasis
GO:0046685 P:response to arsenic

References (2)

[1] “Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon.”  Chen C.-M.et.al.   3021763
[2] “The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.”  Rosen B.P.et.al.   1704144
Structure:
1F48   1IHU   1II0   1II9     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MQFLQNIPPY LFFTGKGGVG KTSISCATAI RLAEQGKRVL LVSTDPASNV GQVFSQTIGI 
61:	TIQAIASVPG LSALEIDPQA AAQQYRARIV DPIKGVLPDD VVSSINEQLS GACTTEIAAF 
121:	DEFTGLLTDA SLLTRFDHII FDTAPTGHTI RLLQLPGAWS SFIDSNPEGA SCLGPMAGLE 
181:	KQREQYAYAV EALSDPKRTR LVLVARLQKS TLQEVARTHL ELAAIGLKNQ YLVINGVLPK 
241:	TEAANDTLAA AIWEREQEAL ANLPADLAGL PTDTLFLQPV NMVGVSALSR LLSTQPVASP 
301:	SSDEYLQQRP DIPSLSALVD DIARNEHGLI MLMGKGGVGK TTMAAAIAVR LADMGFDVHL 
361:	TTSDPAAHLS MTLNGSLNNL QVSRIDPHEE TERYRQHVLE TKGKELDEAG KRLLEEDLRS 
421:	PCTEEIAVFQ AFSRVIREAG KRFVVMDTAP TGHTLLLLDA TGAYHREIAK KMGEKGHFTT 
481:	PMMLLQDPER TKVLLVTLPE TTPVLEAANL QADLERAGIH PWGWIINNSL SIADTRSPLL 
541:	RMRAQQELPQ IESVKRQHAS RVALVPVLAS EPTGIDKLKQ LAG