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3.A.1.3.1
Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium  ligands only one substrate molecule in between its two transmembrane subunits, HisM and HisQ (Heuveling et al. 2019).

Accession Number:P09551
Protein Name:ArgT aka B2310
Length:260
Molecular Weight:27992.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Periplasm1
Substrate Ornithine, Arginine, lysine, Histidine

Cross database links:

Genevestigator: P09551
EchoBASE: EB0070
EcoGene: EG10072
eggNOG: COG0834
HEGENOM: HBG698334
DIP: DIP-9148N
RefSeq: AP_002910.1    NP_416813.1   
Entrez Gene ID: 949030   
Pfam: PF00497   
BioCyc: EcoCyc:ARGT-MONOMER    ECOL168927:B2310-MONOMER   
KEGG: ecj:JW2307    eco:b2310   

Gene Ontology

GO:0030288 C:outer membrane-bounded periplasmic space
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (5)

[1] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “The hisT-purF region of the Escherichia coli K-12 chromosome. Identification of additional genes of the hisT and purF operons.”  Nonet M.L.et.al.   3040734
[5] “Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.”  Link A.J.et.al.   9298646

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKSILALSL LVGLSTAASS YAALPETVRI GTDTTYAPFS SKDAKGDFVG FDIDLGNEMC 
61:	KRMQVKCTWV ASDFDALIPS LKAKKIDAII SSLSITDKRQ QEIAFSDKLY AADSRLIAAK 
121:	GSPIQPTLDS LKGKHVGVLQ GSTQEAYANE TWRSKGVDVV AYANQDLVYS DLAAGRLDAA 
181:	LQDEVAASEG FLKQPAGKDF AFAGSSVKDK KYFGDGTGVG LRKDDAELTA AFNKALGELR 
241:	QDGTYDKMAK KYFDFNVYGD