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3.A.1.3.1
Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium  ligands only one substrate molecule in between its two transmembrane subunits, HisM and HisQ (Heuveling et al. 2019).

Accession Number:P0A2I7
Protein Name:Histidine transport system permease protein HisM aka STM2352
Length:235
Molecular Weight:26453.00
Species:Salmonella typhimurium [90371]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Ornithine, Arginine, lysine, Histidine

Cross database links:

HEGENOM: HBG704821
RefSeq: NP_461294.1   
Entrez Gene ID: 1253874   
Pfam: PF00528   
BioCyc: STYP99287:STM2352-MONOMER   
KEGG: stm:STM2352   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006865 P:amino acid transport

References (3)

[1] “Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium.”  Higgins C.F.et.al.   7050725
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
[3] “Topology of the hydrophobic membrane-bound components of the histidine periplasmic permease. Comparison with other members of the family.”  Kerppola R.E.et.al.   1733937

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIEIIQEYWK SLLWTDGYRF TGVAITLWLL ISSVVMGGLL AVILAVGRVS SNKFIRFPIW 
61:	LFTYIFRGTP LYVQLLVFYS GMYTLEIVKG TDLLNAFFRS GLNCTVLALT LNTCAYTTEI 
121:	FAGAIRSVPH GEIEAARAYG FSSFKMYRCI ILPSALRIAL PAYSNEVILM LHSTALAFTA 
181:	TVPDLLKIAR DINSATYQPF TAFGIAAVLY LLISYVLISL FRRAERRWLQ HVSSK