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5.A.2.1.2
The DsbI (223 aas and 4 TMSs in a 3 + 1 arrangement)/DsbL (222 aas and 1 N-terminal TMS) disulfide bond oxidoreductase/thio:disulfide interchange protein together form a dithiol oxidase system, acting on the periplasmic enzyme arylsulfate sulfotransferase, AssT (598 aas, 1 N-terminal TMS, Q8FDI4) which requires a disulfide bond for activity. The 3-d structure of DsbL at 1.55 Å resolution has been determined. DsbL is one of the most reactive oxidizing thioredoxin-like protein known (Grimshaw et al. 2008).  These three enzymes are encoded within a tricistronic operon.

Accession Number:P0A4L7
Protein Name:Thiol:disulfide interchange protein DsbL
Length:222
Molecular Weight:24381.00
Species:Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [199310]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Periplasm1
Substrate Electrons

Cross database links:

Structure:
3C7M     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSKLGISSLF KTILLTAALA VSFTASAFTE GTDYMVLEKP IPNADKTLIK VFSYACPFCY 
61:	KYDKAVTGPV SEKVKDIVAF TPFHLETKGE YGKQASEVFA VLINKDKAAG ISLFDANSQF 
121:	KKAKFAYYAA YHDKKERWSD GKDPAAFIKT GLDAAGMSQA DFEAALKEPA VQETLEKWKA 
181:	SYDVAKIQGV PAYVVNGKYL IYTKSIKSID AMADLIRELA SK