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3.A.4.1.1
Arsenical resistance efflux pump (ATP-dependent)

Accession Number:P0AB93
Protein Name:Arsenical pump membrane protein ArsB aka ARSF aka B3502
Length:429
Molecular Weight:45497.00
Species:Escherichia coli [83333]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Arsenical

Cross database links:

Genevestigator: P0AB93
EchoBASE: EB2148
EcoGene: EG12236
eggNOG: COG1055
HEGENOM: HBG668021
RefSeq: AP_004291.1    NP_417959.4   
Entrez Gene ID: 948011   
Pfam: PF02040   
Drugbank: Drugbank Link   
BioCyc: EcoCyc:ARSF-MONOMER    ECOL168927:B3502-MONOMER   
KEGG: ecj:JW3469    eco:b3502   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0042960 F:antimonite secondary active transmembrane t...
GO:0008490 F:arsenite secondary active transmembrane tra...
GO:0015699 P:antimonite transport
GO:0015700 P:arsenite transport
GO:0046685 P:response to arsenic

References (6)

[1] “An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in Gram-negative bacteria.”  Diorio C.et.al.   7721697
[2] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase.”  Wu J.et.al.   1535622
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLLAGAIFVL TIVLVIWQPK GLGIGWSATL GAVLALVTGV VHPGDIPVVW NIVWNATAAF 
61:	IAVIIISLLL DESGFFEWAA LHVSRWGNGR GRLLFTWIVL LGAAVAALFA NDGAALILTP 
121:	IVIAMLLALG FSKGTTLAFV MAAGFIADTA SLPLIVSNLV NIVSADFFGL GFREYASVMV 
181:	PVDIAAIVAT LVMLHLYFRK DIPQNYDMAL LKSPAEAIKD PATFKTGWVV LLLLLVGFFV 
241:	LEPLGIPVSA IAAVGALILF VVAKRGHAIN TGKVLRGAPW QIVIFSLGMY LVVYGLRNAG 
301:	LTEYLSGVLN VLADNGLWAA TLGTGFLTAF LSSIMNNMPT VLVGALSIDG STASGVIKEA 
361:	MVYANVIGCD LGPKITPIGS LATLLWLHVL SQKNMTISWG YYFRTGIIMT LPVLFVTLAA 
421:	LALRLSFTL