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9.A.39.1.2
Iron regulated surface determinant, Haptoglobin receptor A (HarA or IsdH) precursor (891 aas). Also binds hemoglobin and haptoglobin/hemoglobin complexes with nM or µM binding constants to an 8-stranded anti-parallel β-barrel domain (Dryla et al., 2007). The functionally distinct NEAT (NEAr Transporter) domain within IsdH extracts heme from methemoglobin (Pilpa et al., 2009). Hemoglobin/myoglobin receptor B (IsdB), transferrin, hemin, fetuin, asialofetuin receptor (IsdA), and the cell wall conduit, IsdC may comprise the full system (Villareal et al., 2008).

Accession Number:P0C1S5
Protein Name:IsdA
Length:354
Molecular Weight:39133.00
Species:Staphylococcus aureus [1280]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1 / Peptidoglycan-anchor2
Substrate iron-heme complex

Cross database links:

Pfam: PF00746    PF05031   

Gene Ontology

GO:0009986 C:cell surface
GO:0005618 C:cell wall
GO:0005576 C:extracellular region
GO:0046872 F:metal ion binding

References (6)

[1] “Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.”  Taylor J.M.et.al.   11952908
[2] “Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron.”  Park R.-Y.et.al.   15880095
[3] “Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage.”  Clarke S.R.et.al.   16544250
[4] “Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein.”  Taylor J.M.et.al.   11952908
[5] “Staphylococcus aureus siderophore-mediated iron-acquisition system plays a dominant and essential role in the utilization of transferrin-bound iron.”  Park R.-Y.et.al.   15880095
[6] “Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage.”  Clarke S.R.et.al.   16544250

External Searches:

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Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTKHYLNSKY QSEQRSSAMK KITMGTASII LGSLVYIGAD SQQVNAATEA TNATNNQSTQ 
61:	VSQATSQPIN FQVQKDGSSE KSHMDDYMQH PGKVIKQNNK YYFQAVLNNA SFWKEYKFYN 
121:	ANNQELATTV VNDDKKADTR TINVAVEPGY KSLTTKVHIV VPQINYNHRY TTHLEFEKAI 
181:	PTLADAAKPN NVKPVQPKPA QPKTPTEQTK PVQPKVEKVK PAVTAPSKNE NRQTTKVVSS 
241:	EATKDQSQTQ SARTVKTTQT AQDQNKVQTP VKDVATAKSE SNNQAVSDNK SQQTNKVTKQ 
301:	NEVHKQGPSK DSKAKELPKT GLTSVDNFIS TVAFATLALL GSLSLLLFKR KESK