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3.A.1.1.3
Glycerol-phosphate porter. Transports both glycerol-3-P and glycerol-3-P diesters including glycerophosphocholine but not glycerol-2-P (Yang et al. 2009; Wuttge et al. 2012).  UgpB (the receptor) binds glycerol 3-P with high affinity, but not glycerol 2-P (Wuttge et al. 2012).  UgpB (the receptor) binds glycerol 3-P with high affinity, but not glycerol 2-P (Wuttge et al. 2012).

Accession Number:P10907
Protein Name:UgpC aka B3450
Length:356
Molecular Weight:39524.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2
Substrate Glycerol-phosphate

Cross database links:

Genevestigator: P10907
EchoBASE: EB1041
EcoGene: EG11048
eggNOG: COG3839
HEGENOM: HBG758042
DIP: DIP-11079N
RefSeq: AP_004342.1    NP_417907.2   
Entrez Gene ID: 947953   
Pfam: PF00005    PF08402   
BioCyc: EcoCyc:UGPC-MONOMER    ECOL168927:B3450-MONOMER   
KEGG: ecj:JW3415    eco:b3450   

Gene Ontology

GO:0043190 C:ATP-binding cassette (ABC) transporter complex
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0015430 F:glycerol-3-phosphate-transporting ATPase ac...
GO:0070811 P:glycerol-2-phosphate transport
GO:0015794 P:glycerol-3-phosphate transport

References (12)

[1] “Nucleotide sequence of the ugp genes of Escherichia coli K-12: homology to the maltose system.”  Overduin P.et.al.   3062310
[2] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “A second transport system for sn-glycerol-3-phosphate in Escherichia coli.”  Argast M.et.al.   363686
[6] “Characteristics of a binding protein-dependent transport system for sn-glycerol-3-phosphate in Escherichia coli that is part of the pho regulon.”  Schweizer H.et.al.   7042685
[7] “Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli.”  Brzoska P.et.al.   2842304
[8] “Dual regulation of the ugp operon by phosphate and carbon starvation at two interspaced promoters.”  Kasahara M.et.al.   1987150
[9] “Functional exchangeability of the ABC proteins of the periplasmic binding protein-dependent transport systems Ugp and Mal of Escherichia coli.”  Hekstra D.et.al.   8407831
[10] “The pho regulon-dependent Ugp uptake system for glycerol-3-phosphate in Escherichia coli is trans inhibited by Pi.”  Brzoska P.et.al.   8282692
[11] “Kinetic analysis by in vivo 31P nuclear magnetic resonance of internal Pi during the uptake of sn-glycerol-3-phosphate by the pho regulon-dependent Ugp system and the glp regulon-dependent GlpT system.”  Xavier K.B.et.al.   7836304
[12] “Binding protein-dependent ABC transport system for glycerol 3-phosphate of Escherichia coli.”  Boos W.et.al.   9711545

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGLKLQAVT KSWDGKTQVI KPLTLDVADG EFIVMVGPSG CGKSTLLRMV AGLERVTEGD 
61:	IWINDQRVTE MEPKDRGIAM VFQNYALYPH MSVEENMAWG LKIRGMGKQQ IAERVKEAAR 
121:	ILELDGLLKR RPRELSGGQR QRVAMGRAIV RDPAVFLFDE PLSNLDAKLR VQMRLELQQL 
181:	HRRLKTTSLY VTHDQVEAMT LAQRVMVMNG GVAEQIGTPV EVYEKPASLF VASFIGSPAM 
241:	NLLTGRVNNE GTHFELDGGI ELPLNGGYRQ YAGRKMTLGI RPEHIALSSQ AEGGVPMVMD 
301:	TLEILGADNL AHGRWGEQKL VVRLAHQERP TAGSTLWLHL AENQLHLFDG ETGQRV