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3.A.6.2.1
Flagellar protein export system.  Infrequent ATP hydrolysis by the FliI6FliJ ring is sufficient for gate activation, allowing processive translocation of export flagellar protein substrates for efficient flagellar assembly (Minamino et al. 2014). FliO has been identified as a flagellar basal body chaparone protein (Fabiani et al. 2017). The flagellar protein export apparatus switches its substrate specificity when hook length has reached approximately 55 nm, and the hydrophilic C-terminal domain of FlhB is involved in this switching process (Inoue et al. 2019).

Accession Number:P15928
Protein Name:FliF aka FLA BI aka FLA AII.1 aka STM1969
Length:560
Molecular Weight:61230.00
Species:Salmonella typhimurium [90371]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Flagellar proteins

Cross database links:

HEGENOM: HBG661951
RefSeq: NP_460922.1   
Entrez Gene ID: 1253490   
Pfam: PF01514    PF08345   
BioCyc: STYP99287:STM1969-MONOMER   
KEGG: stm:STM1969   

Gene Ontology

GO:0009431 C:bacterial-type flagellum basal body, MS ring
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0003774 F:motor activity
GO:0005515 F:protein binding
GO:0001539 P:ciliary or flagellar motility

References (3)

[1] “L-, P-, and M-ring proteins of the flagellar basal body of Salmonella typhimurium: gene sequences and deduced protein sequences.”  Jones C.J.et.al.   2544561
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
[3] “Characterization of the fliE genes of Escherichia coli and Salmonella typhimurium and identification of the FliE protein as a component of the flagellar hook-basal body complex.”  Mueller V.et.al.   1551848

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSATASTATQ PKPLEWLNRL RANPRIPLIV AGSAAVAIVV AMVLWAKTPD YRTLFSNLSD 
61:	QDGGAIVAQL TQMNIPYRFA NGSGAIEVPA DKVHELRLRL AQQGLPKGGA VGFELLDQEK 
121:	FGISQFSEQV NYQRALEGEL ARTIETLGPV KSARVHLAMP KPSLFVREQK SPSASVTVTL 
181:	EPGRALDEGQ ISAVVHLVSS AVAGLPPGNV TLVDQSGHLL TQSNTSGRDL NDAQLKFAND 
241:	VESRIQRRIE AILSPIVGNG NVHAQVTAQL DFANKEQTEE HYSPNGDASK ATLRSRQLNI 
301:	SEQVGAGYPG GVPGALSNQP APPNEAPIAT PPTNQQNAQN TPQTSTSTNS NSAGPRSTQR 
361:	NETSNYEVDR TIRHTKMNVG DIERLSVAVV VNYKTLADGK PLPLTADQMK QIEDLTREAM 
421:	GFSDKRGDTL NVVNSPFSAV DNTGGELPFW QQQSFIDQLL AAGRWLLVLV VAWILWRKAV 
481:	RPQLTRRVEE AKAAQEQAQV RQETEEAVEV RLSKDEQLQQ RRANQRLGAE VMSQRIREMS 
541:	DNDPRVVALV IRQWMSNDHE