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3.A.18.1.1
The nuclear mRNA Export Complex (mRNA-E also called TREX) (including the exon junction complex) [TAP+p15 interact as a complex with the nuclear pore to facilitate mRNA transport to the cytoplasm] (Nojimma et al. 2007; Cheng et al., 2006)

Accession Number:P18583
Protein Name:Protein SON
Length:2426
Molecular Weight:263830.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Nucleus speckle1
Substrate mRNA

Cross database links:

Genevestigator: P18583
Entrez Gene ID: 6651   
Pfam: PF01585   
KEGG: hsa:6651   

Gene Ontology

GO:0016607 C:nuclear speck
GO:0003677 F:DNA binding
GO:0003725 F:double-stranded RNA binding
GO:0006916 P:anti-apoptosis
GO:0000910 P:cytokinesis
GO:0006397 P:mRNA processing
GO:0051726 P:regulation of cell cycle
GO:0043484 P:regulation of RNA splicing
GO:0008380 P:RNA splicing
GO:0000073 P:spindle pole body separation

References (29)

[1] “From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.”  Reymond A.et.al.   11707072
[2] “Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON.”  Sun C.-T.et.al.   11306577
[3] “Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”  Kikuno R.et.al.   10470851
[4] “The DNA sequence of human chromosome 21.”  Hattori M.et.al.   10830953
[5] “mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs.”  Casadei R.et.al.   14637006
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Identification of a protein product of a novel human gene SON and the biological effect upon administering a changed form of this gene into mammalian cells.”  Chumakov I.M.et.al.   1944255
[9] “The human SON gene: the large and small transcripts contains various 5'-terminal sequences.”  Bliskovskii V.V.et.al.   1435774
[10] “Coding part of the son gene small transcript contains four areas of complete tandem repeats.”  Bliskovskii V.V.et.al.   1435773
[11] “A cDNA clone for a novel nuclear protein with DNA binding activity.”  Mattioni T.et.al.   1424986
[12] “Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins.”  Berdichevskii F.B.et.al.   3054499
[13] “A selection system for human apoptosis inhibitors using yeast.”  Greenhalf W.et.al.   10509013
[14] “An unappreciated role for RNA surveillance.”  Hillman R.T.et.al.   14759258
[15] “Large-scale characterization of HeLa cell nuclear phosphoproteins.”  Beausoleil S.A.et.al.   15302935
[16] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[17] “Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.”  Kim S.C.et.al.   16916647
[18] “A probability-based approach for high-throughput protein phosphorylation analysis and site localization.”  Beausoleil S.A.et.al.   16964243
[19] “Phosphoproteome analysis of the human mitotic spindle.”  Nousiainen M.et.al.   16565220
[20] “Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.”  Molina H.et.al.   17287340
[21] “Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.”  Wang B.et.al.   19007248
[22] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[23] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[24] “Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.”  Ahn E.Y.et.al.   18952841
[25] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[26] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332
[27] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[28] “SON is a spliceosome-associated factor required for mitotic progression.”  Huen M.S.et.al.   20581448
[29] “SON controls cell-cycle progression by coordinated regulation of RNA splicing.”  Ahn E.Y.et.al.   21504830

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 
61:	IVQKIEEVLS GVLDTELRYK PDLKEGSRKS RCVSVQTDPT DEIPTKKSKK HKKHKNKKKK 
121:	KKKEKEKKYK RQPEESESKT KSHDDGNIDL ESDSFLKFDS EPSAVALELP TRAFGPSETN 
181:	ESPAVVLEPP VVSMEVSEPH ILETLKPATK TAELSVVSTS VISEQSEQSV AVMPEPSMTK 
241:	ILDSFAAAPV PTTTLVLKSS EPVVTMSVEY QMKSVLKSVE STSPEPSKIM LVEPPVAKVL 
301:	EPSETLVVSS ETPTEVYPEP STSTTMDFPE SSAIEALRLP EQPVDVPSEI ADSSMTRPQE 
361:	LPELPKTTAL ELQESSVASA MELPGPPATS MPELQGPPVT PVLELPGPSA TPVPELPGPL 
421:	STPVPELPGP PATAVPELPG PSVTPVPQLS QELPGLPAPS MGLEPPQEVP EPPVMAQELP 
481:	GLPLVTAAVE LPEQPAVTVA MELTEQPVTT TELEQPVGMT TVEHPGHPEV TTATGLLGQP 
541:	EATMVLELPG QPVATTALEL PGQPSVTGVP ELPGLPSATR ALELSGQPVA TGALELPGPL 
601:	MAAGALEFSG QSGAAGALEL LGQPLATGVL ELPGQPGAPE LPGQPVATVA LEISVQSVVT 
661:	TSELSTMTVS QSLEVPSTTA LESYNTVAQE LPTTLVGETS VTVGVDPLMA PESHILASNT 
721:	METHILASNT MDSQMLASNT MDSQMLASNT MDSQMLASST MDSQMLATSS MDSQMLATSS 
781:	MDSQMLATST MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATSS MDSQMLATST 
841:	MDSQMLATST MDSQMLATSS MDSQMLASGT MDSQMLASGT MDAQMLASGT MDAQMLASST 
901:	QDSAMLGSKS PDPYRLAQDP YRLAQDPYRL GHDPYRLGHD AYRLGQDPYR LGHDPYRLTP 
961:	DPYRMSPRPY RIAPRSYRIA PRPYRLAPRP LMLASRRSMM MSYAAERSMM SSYERSMMSY 
1021:	ERSMMSPMAE RSMMSAYERS MMSAYERSMM SPMAERSMMS AYERSMMSAY ERSMMSPMAD 
1081:	RSMMSMGADR SMMSSYSAAD RSMMSSYSAA DRSMMSSYTA DRSMMSMAAD SYTDSYTDTY 
1141:	TEAYMVPPLP PEEPPTMPPL PPEEPPMTPP LPPEEPPEGP ALPTEQSALT AENTWPTEVP 
1201:	SSPSEESVSQ PEPPVSQSEI SEPSAVPTDY SVSASDPSVL VSEAAVTVPE PPPEPESSIT 
1261:	LTPVESAVVA EEHEVVPERP VTCMVSETPA MSAEPTVLAS EPPVMSETAE TFDSMRASGH 
1321:	VASEVSTSLL VPAVTTPVLA ESILEPPAMA APESSAMAVL ESSAVTVLES STVTVLESST 
1381:	VTVLEPSVVT VPEPPVVAEP DYVTIPVPVV SALEPSVPVL EPAVSVLQPS MIVSEPSVSV 
1441:	QESTVTVSEP AVTVSEQTQV IPTEVAIEST PMILESSIMS SHVMKGINLS SGDQNLAPEI 
1501:	GMQEIALHSG EEPHAEEHLK GDFYESEHGI NIDLNINNHL IAKEMEHNTV CAAGTSPVGE 
1561:	IGEEKILPTS ETKQRTVLDT YPGVSEADAG ETLSSTGPFA LEPDATGTSK GIEFTTASTL 
1621:	SLVNKYDVDL SLTTQDTEHD MVISTSPSGG SEADIEGPLP AKDIHLDLPS NNNLVSKDTE 
1681:	EPLPVKESDQ TLAALLSPKE SSGGEKEVPP PPKETLPDSG FSANIEDINE ADLVRPLLPK 
1741:	DMERLTSLRA GIEGPLLASD VGRDRSAASP VVSSMPERAS ESSSEEKDDY EIFVKVKDTH 
1801:	EKSKKNKNRD KGEKEKKRDS SLRSRSKRSK SSEHKSRKRT SESRSRARKR SSKSKSHRSQ 
1861:	TRSRSRSRRR RRSSRSRSKS RGRRSVSKEK RKRSPKHRSK SRERKRKRSS SRDNRKTVRA 
1921:	RSRTPSRRSR SHTPSRRRRS RSVGRRRSFS ISPSRRSRTP SRRSRTPSRR SRTPSRRSRT 
1981:	PSRRSRTPSR RSRTPSRRRR SRSVVRRRSF SISPVRLRRS RTPLRRRFSR SPIRRKRSRS 
2041:	SERGRSPKRL TDLDKAQLLE IAKANAAAMC AKAGVPLPPN LKPAPPPTIE EKVAKKSGGA 
2101:	TIEELTEKCK QIAQSKEDDD VIVNKPHVSD EEEEEPPFYH HPFKLSEPKP IFFNLNIAAA 
2161:	KPTPPKSQVT LTKEFPVSSG SQHRKKEADS VYGEWVPVEK NGEENKDDDN VFSSNLPSEP 
2221:	VDISTAMSER ALAQKRLSEN AFDLEAMSML NRAQERIDAW AQLNSIPGQF TGSTGVQVLT 
2281:	QEQLANTGAQ AWIKKDQFLR AAPVTGGMGA VLMRKMGWRE GEGLGKNKEG NKEPILVDFK 
2341:	TDRKGLVAVG ERAQKRSGNF SAAMKDLSGK HPVSALMEIC NKRRWQPPEF LLVHDSGPDH 
2401:	RKHFLFRVLR NGALTRPNCM FFLNRY