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3.A.1.2.6
D-allose porter.  The structure of AlsB has been solved at 1.8 Å resolution (Chaudhuri et al. 1999). Ten residues from both the domains form 14 hydrogen bonds with the sugar. 6-Deoxy-allose, 3-deoxy-glucose and ribose bind with reduced affinity so AlbP can function as a low affinity transporter for D-ribose (Chaudhuri et al. 1999).

Accession Number:P32721
Protein Name:AlsA aka B4087
Length:510
Molecular Weight:56745.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Peripheral membrane protein2
Substrate Allose

Cross database links:

Genevestigator: P32721
EchoBASE: EB1902
EcoGene: EG11959
eggNOG: COG1129
HEGENOM: HBG758042
DIP: DIP-9093N
RefSeq: AP_004589.1    NP_418511.1   
Entrez Gene ID: 948593   
Pfam: PF00005   
Drugbank: Drugbank Link   
BioCyc: EcoCyc:YJCW-MONOMER    ECOL168927:B4087-MONOMER   
KEGG: ecj:JW4048    eco:b4087   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0015407 F:monosaccharide-transporting ATPase activity
GO:0005515 F:protein binding
GO:0008643 P:carbohydrate transport

References (5)

[1] “Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.”  Burland V.D.et.al.   7610040
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.”  Blattner F.R.et.al.   8265357
[5] “The D-allose operon of Escherichia coli K-12.”  Kim C.et.al.   9401019

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATPYISMAG IGKSFGPVHA LKSVNLTVYP GEIHALLGEN GAGKSTLMKV LSGIHEPTKG 
61:	TITINNISYN KLDHKLAAQL GIGIIYQELS VIDELTVLEN LYIGRHLTKK ICGVNIIDWR 
121:	EMRVRAAMML LRVGLKVDLD EKVANLSISH KQMLEIAKTL MLDAKVIIMD EPTSSLTNKE 
181:	VDYLFLIMNQ LRKEGTAIVY ISHKLAEIRR ICDRYTVMKD GSSVCSGIVS DVSNDDIVRL 
241:	MVGRELQNRF NAMKENVSNL AHETVFEVRN VTSRDRKKVR DISFSVCRGE ILGFAGLVGS 
301:	GRTELMNCLF GVDKRAGGEI RLNGKDISPR SPLDAVKKGM AYITESRRDN GFFPNFSIAQ 
361:	NMAISRSLKD GGYKGAMGLF HEVDEQRTAE NQRELLALKC HSVNQNITEL SGGNQQKVLI 
421:	SKWLCCCPEV IIFDEPTRGI DVGAKAEIYK VMRQLADDGK VILMVSSELP EIITVCDRIA 
481:	VFCEGRLTQI LTNRDDMSEE EIMAWALPQE