TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.5.27
The glutathione uptake porter, DppBCDF with the glutathione binding protein, DppA (GbpA; HbpA). Takes up reduced (GSH) and oxidized (GSSG) but not bulky glutathione S conjugates or glutathione derivatives with C-terminal modifications (Vergauwen et al., 2010).

Accession Number:P33950
Protein Name:Heme-binding protein A
Length:547
Molecular Weight:60661.00
Species:Haemophilus influenzae [727]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Lipid-anchor2
Substrate Glutathione

Cross database links:

HEGENOM: HBG688042
Entrez Gene ID: 949866   
Pfam: PF00496   
KEGG: hin:HI0853   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity

References (3)

[1] “The hbpA gene of Haemophilus influenzae type b encodes a heme-binding lipoprotein conserved among heme-dependent Haemophilus species.”  Hanson M.S.et.al.   1339409
[2] “Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.”  Fleischmann R.D.et.al.   7542800
[3] “Molecular cloning, partial purification, and characterization of a haemin-binding lipoprotein from Haemophilus influenzae type b.”  Hanson M.S.et.al.   2041470

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKLKATLTLA AATLVLAACD QSSSANKSTA QTEAKSSSNN TFVYCTAKAP LGFSPALIIE 
61:	GTSYNASSQQ VYNRLVEFKK GSTDIEPALA ESWEISDDGL SYTFHLRKGV KFHTTKEFTP 
121:	TRDFNADDVV FSFQRQLDPN HPYHNVSKGT YPYFKAMKFP ELLKSVEKVD DNTIRITLNK 
181:	TDATFLASLG MDFISIYSAE YADSMLKAGK PETLDSRPVG TGPFVFVDYK TDQAIQYVAH 
241:	ENYWKGRTPL DRLVISIVPD ATTRYAKLQA GTCDLILFPN VADLAKMKTD PKVQLLEQKG 
301:	LNVAYIAFNT EKAPFDNVKV RQALNYAVDK KAIIEAVYQG AGTSAKNPLP PTIWSYNDEI 
361:	QDYPYDPEKA KQLLAEAGYP NGFETDFWIQ PVIRASNPNP KRMAELIMAD WAKIGVKTNP 
421:	VTYEWADYRK RAKEGELTAG IFGWSGDNGD PDNFLSPLLG SSNIGNSNMA RFNNSEFDAL 
481:	LNEAIGLTNK EERAKLYKQA QVIVHNQAPW IPVAHSVGFA PLSPRVKGYV QSPFGYDAFY 
541:	GVSVDGK