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1.A.6.2.2
Touch-responsive mechanosensitive degenerin channel complex (Mec-4/Mec-10 form the cation/Ca2+-permeable channel; Mec-2 and Mec-6 regulate) (Bianchi, 2007; Chelur et al., 2002; ). Mec-6 is a chaparone protein required for functional insertion (Matthewman et al. 2018). Mec-10 plays a role in the response to mechanical forces such as laminar shear stress (Shi et al. 2016). MEC-4 or MEC-10 mutants that alter the channel's LSS response are primarily clustered between the degenerin site and the selectivity filter, a region that likely forms the narrowest portion of the channel pore (Shi et al. 2018). TMS2 forms the Ca2+ channel of Mec-4.  A C-terminal domain affects trafficking of a neuronally expressed DEG/ENaC. Neuronal swelling occurs prior to commitment to necrotic death (Royal et al. 2005).

Accession Number:P34886
Protein Name:Mec-10
Length:724
Molecular Weight:82382.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

eggNOG: meNOG13575
HEGENOM: HBG388583
RefSeq: NP_509438.1   
Entrez Gene ID: 181101   
Pfam: PF00858   
KEGG: cel:F16F9.5   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005272 F:sodium channel activity
GO:0050896 P:response to stimulus
GO:0006814 P:sodium ion transport

References (5)

[1] “Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans.”  Huang M.et.al.   7509039
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation.”  Goodman M.B.et.al.   11875573
[4] “The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel.”  Chelur D.S.et.al.   12478294
[5] “Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.”  Brown A.L.et.al.   17261841

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRNPRMSKF QPNPRSRSRF QDETDLRSLR SFKTDFSNYL ASDTNFLNVA EIMTSYAYGE 
61:	SNNAHEKEIQ CDLLTENGGI EIDPTRLSYR ERIRWHLQQF CYKTSSHGIP MLGQAPNSLY 
121:	RAAWVFLLLI CAIQFINQAV AVIQKYQKMD KITDIQLKFD TAPFPAITLC NLNPYKDSVI 
181:	RSHDSISKIL GVFKSVMKKA GDSSSEALEE EEETEYDMNG ITIQAKRKKR GAGEKGTFEP 
241:	ANSACECDEE DGSNECEERS TEKPSGDNDM CICAFDRQTN DAWPCHRKEQ WTNTTCQTCD 
301:	EHYLCSKKAK KGTKRSELKK EPCICESKGL FCIKHEHAAM VLNLWEYFGD SEDFSEISTE 
361:	EREALGFGNM TDEVAIVTKA KENIIFAMSA LSEEQRILMS QAKHNLIHKC SFNGKPCDID 
421:	QDFELVADPT FGNCFVFNHD REIFKSSVRA GPQYGLRVML FVNASDYLPT SEAVGIRLTI 
481:	HDKDDFPFPD TFGYSAPTGY ISSFGMRMKK MSRLPAPYGD CVEDGATSNY IYKGYAYSTE 
541:	GCYRTCFQEL IIDRCGCSDP RFPSIGGVQP CQVFNKNHRE CLEKHTHQIG EIHGSFKCRC 
601:	QQPCNQTIYT TSYSEAIWPS QALNISLGQC EKEAEECNEE YKENAAMLEV FYEALNFEVL 
661:	SESEAYGIVK MMADFGGHLG LWSGVSVMTC CEFVCLAFEL IYMAIAHHIN QQRIRRRENA 
721:	ANEY