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1.A.9.2.2
The heteromeric serotonin 5HT3A receptor (Hanna et al., 2000)

Accession Number:P35563
Protein Name:5-hydroxytryptamine 3 receptor aka Htr3a aka 5HT3A
Length:483
Molecular Weight:55428.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Genevestigator: P35563
RefSeq: NP_077370.2   
Entrez Gene ID: 79246   
Pfam: PF02931    PF02932   
KEGG: rno:79246   

Gene Ontology

GO:0030424 C:axon
GO:0030054 C:cell junction
GO:0005737 C:cytoplasm
GO:0005887 C:integral to plasma membrane
GO:0043025 C:neuronal cell body
GO:0045211 C:postsynaptic membrane
GO:0004872 F:receptor activity
GO:0005232 F:serotonin-activated cation-selective channe...
GO:0005249 F:voltage-gated potassium channel activity
GO:0071363 P:cellular response to growth factor stimulus
GO:0006811 P:ion transport
GO:0042220 P:response to cocaine
GO:0007268 P:synaptic transmission

References (4)

[1] “Partial cDNA cloning and NGF regulation of a rat 5-HT3 receptor subunit.”  Isenberg K.E.et.al.   7509203
[2] “Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents.”  Hanna M.C.et.al.   10854267
[3] “Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system.”  Morales M.et.al.   12151552
[4] “A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.”  Kelley S.P.et.al.   12867984

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPLCIPQVLL ALFLSVLIAQ GEGSRRRATQ AHSTTQPALL RLSDHLLANY KKGVRPVRDW 
61:	RKPTLVSIDV IMYAILNVDE KNQVLTTYIW YRQFWTDEFL QWTPEDFDNV TKLSIPTDSI 
121:	WVPDILINEF VDVGKSPSIP YVYVHHQGEV QNYKPLQLVT ACSLDIYNFP FDVQNCSLTF 
181:	TSWLHTIQDI NISLWRTPEE VRSDKSIFIN QGEWELLGVF TKFQEFSIET SNSYAEMKFY 
241:	VVIRRRPLFY AVSLLLPSIF LMVVDIVGFC LPPDSGERVS FKITLLLGYS VFLIIVSDTL 
301:	PATAIGTPLI GVYFVVCMAL LVISLAETIF IVQLVHKQDL QRPVPDWLRH LVLDRIAWLL 
361:	CLGEQPMAHR PPATFQANKT DDCSAMGNHC SHVGSPQDLE KTSRSRDSPL PPPREASLAV 
421:	RGLLQELSSI RHSLEKRDEM REVARDWLRV GYVLDRLLFR IYLLAVLAYS ITLVTLWSIW 
481:	HYS