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3.A.6.2.1
Flagellar protein export system.  Infrequent ATP hydrolysis by the FliI6FliJ ring is sufficient for gate activation, allowing processive translocation of export flagellar protein substrates for efficient flagellar assembly (Minamino et al. 2014). FliO has been identified as a flagellar basal body chaparone protein (Fabiani et al. 2017). The flagellar protein export apparatus switches its substrate specificity when hook length has reached approximately 55 nm, and the hydrophilic C-terminal domain of FlhB is involved in this switching process (Inoue et al. 2019).

Accession Number:P40729
Protein Name:FlhA aka STM1913
Length:692
Molecular Weight:74849.00
Species:Salmonella typhimurium [90371]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Flagellar proteins

Cross database links:

HEGENOM: HBG595253
RefSeq: NP_460870.1   
Entrez Gene ID: 1253434   
Pfam: PF00771   
BioCyc: STYP99287:STM1913-MONOMER   
KEGG: stm:STM1913   

Gene Ontology

GO:0019861 C:flagellum
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0043064 P:flagellum organization
GO:0009306 P:protein secretion

References (2)

[1] “Molecular characterization of the Salmonella typhimurium flhB operon and its protein products.”  Minamino T.et.al.   8002587
[2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
Structure:
3A5I     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANLVAMLRL PSNLKSTQWQ ILAGPILILL ILSMMVLPLP AFILDLLFTF NIALSIMVLL 
61:	VAMFTQRTLD FAAFPTILLF TTLLRLALNV ASTRIILMEG HTGAAAAGKV VEAFGHFLVG 
121:	GNFAIGIVVF IILVIINFMV ITKGAGRIAE VGARFVLDGM PGKQMAIDAD LNAGLIGEDE 
181:	AKKRRSEVTQ EADFYGSMDG ASKFVRGDAI AGILIMVINV VGGLLVGVLQ HGMSIGSAAE 
241:	SYTLLTIGDG LVAQIPALVI STAAGVIVTR VSTDQDVGEQ MVGQLFSNPR VMLLAAAVLG 
301:	LLGMVPGMPN LVFLLFTAAL LGLAWWLRGR EEKAPEEPQP VKMPENNSVV EATWNDVQLE 
361:	DSLGMEVGYR LIPMVDFQQD GELLGRIRSI RKKFAQDMGF LPPVVHIRDN MDLQPARYRI 
421:	LMKGVEIGSG DAYPGRWLAI NPGTAAGTLP GEKTVDPAFG LDAIWIESAL KEQAQIQGFT 
481:	VVEASTVVAT HLNHLIGQFS AELFGRQEAQ QLLDRVSQEM PKLTEDLVPG VVTLTTLHKV 
541:	LQNLLAEKVP IRDMRTILET LAEHAPLQSD PHELTAVVRV ALGRAITQQW FPGNEEVQVI 
601:	GLDTALERLL LQALQGGGGL EPGLADRLLA QTQEALSRQE MLGAPPVLLV NHALRPLLSR 
661:	FLRRSLPQLV VLSNLELSDN RHIRMTATIG GK