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3.A.1.131.1
The 2 or 3 component bacitracin-resistance efflex pump, BcrAB or BcrABC (Podlesek et al., 1995; Bernard et al., 2003) (BcrA is most similar to SpaF (3.A.1.124.2), but BcrB (5-6 TMSs) is only distantly related to other ABC2-type membrane proteins (Wang et al., 2009). BcrC is not sufficiently similar to detect similarity in BLAST searches. BcrC (5TMSs) belongs to the PAP2 phosphatase superfamily and may not be a contituent of the BcrAB transporter. Transcription is regulated by BcrR, a one-component transmembrane signal transduction system (Darnell et al. 2019).

Accession Number:P42333
Protein Name:BcrB
Length:208
Molecular Weight:23324.00
Species:Bacillus licheniformis [1402]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Bacitracin

Cross database links:

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046677 P:response to antibiotic
GO:0006810 P:transport

References (2)

[1] “Bacillus licheniformis bacitracin-resistance ABC transporter: relationship to mammalian multidrug resistance.”  Podlesek Z.et.al.   7476193
[2] “The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases.”  Konz D.et.al.   9427658

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKKAKYPDV PIRFSETFSD TNLYIVLLIG VPLYGVITSY LFNREYAEST LKNLLTIPVS 
61:	RISLIVSKLV LLLIWIMMLT LIAWVLTLLF GLIGQFEGLS SAVLIEGFKQ FMIGGALLFF 
121:	LVSPIIFVTL LFKNYVPTII FTIIISMVSI MVYGTEYSAL FPWSAVWVIA SGTFFPEYPP 
181:	EYSFISVAAT TVLGLAATIV YFKKIDIH