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3.A.1.134.6
The cationic peptide/MDR exporter, YxdLM. Possibly linked to a sensor kinase/reponse regulator system (YxdJK) (Joseph et al., 2002; Bernard et al., 2007).

Accession Number:P42424
Protein Name:ABC transporter permease protein yxdM
Length:622
Molecular Weight:70477.00
Species:Bacillus subtilis [1423]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cationic peptides, drugs

Cross database links:

HEGENOM: HBG425420
Entrez Gene ID: 937589   
Pfam: PF02687   
KEGG: bsu:BSU39630   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (6)

[1] “Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome between the iol and hut operons.”  Yoshida K.et.al.   8867804
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.”  Barbe V.et.al.   19383706
[4] “Cloning and nucleotide sequencing of a 15 kb region of the Bacillus subtilis genome containing the iol operon.”  Yoshida K.et.al.   7952181
[5] “Characterization of the Bacillus subtilis YxdJ response regulator as the inducer of expression for the cognate ABC transporter YxdLM.”  Joseph P.et.al.   15289557
[6] “Cationic antimicrobial peptides elicit a complex stress response in Bacillus subtilis that involves ECF-type sigma factors and two-component signal transduction systems.”  Pietiaeinen M.et.al.   15870467

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTFLQFAYKN VTRNKRAYLA FFLSSAFSVL IFFTFAMFLF HPALKEGYLN NIAKKGLTAA 
61:	EWMIFVFSFL FVLYSVNAFL KSRNKEFGIL LMQGITPGQL RKLITAENMI IGVMSIAAGI 
121:	IGGFIFSKTF FTVGAYILEM DALPLYMPWK ALGITACGFL LLFFFLSQFT ILFVRSNTVI 
181:	KLIKGTGKVK PEPKPSVLLS LFGIACLCGG YGMVLKGNVH GAEPFIILLL TVIGTYFFFS 
241:	QSSIWILRAL KKWKTFYLRG KNIIWVSDLV YRLKDNARLF FIVSIISAVA FTATGVLAMY 
301:	KSTVGAEESA YEMEYLSYSN NPKEQTHLKD IDHELKTHGF TYTKDKIDVS YVRYQEGETV 
361:	PPVYMISESD AAKYFHVKVN GLKEDEAVYF PGTYDRNFKN EAPDQLKLLN QKGELSDQKL 
421:	SVKEVKKPLI SLNAIIAVND QTFDQLKSLG DKASLYGYSY DHWKDSLEIS QSLQNEIYGN 
481:	YIDVHSDFAS KAGTYYDTVQ LPSLSLFIGL FIAIVFFVAA ASFLYFRLFT DLDEDRERYR 
541:	SLAKIGLSER EMAQSVTIQL AILFFFPFVI AVMHTLFALR TLAVEGYSDV AGPLSLTIGG 
601:	FFIFQLLFFL AVRSSYLKKM NK