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9.A.48.1.1
The Unconventional Protein Secretion System, UPSS (Giuliani et al., 2011).  Secretes FGF1 and Epimorphin (syntaxin 2) (Hirai et al. 2007)

Accession Number:P46096
Protein Name:Syt1 aka Synaptotagmin-1
Length:421
Molecular Weight:47418.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Single-pass membrane protein2
Substrate proteins

Cross database links:

Genevestigator: P46096
eggNOG: roNOG10139
HEGENOM: HBG716633
RefSeq: NP_033332.1   
Entrez Gene ID: 20979   
Pfam: PF00168   
KEGG: mmu:20979   

Gene Ontology

GO:0030054 C:cell junction
GO:0042584 C:chromaffin granule membrane
GO:0016021 C:integral to membrane
GO:0043005 C:neuron projection
GO:0042734 C:presynaptic membrane
GO:0030672 C:synaptic vesicle membrane
GO:0005509 F:calcium ion binding
GO:0005544 F:calcium-dependent phospholipid binding
GO:0048306 F:calcium-dependent protein binding
GO:0005215 F:transporter activity
GO:0007269 P:neurotransmitter secretion

References (6)

[1] “Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II.”  Fukuda M.et.al.   7961887
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “SV2B regulates synaptotagmin 1 by direct interaction.”  Lazzell D.R.et.al.   15466855
[5] “Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.”  Ballif B.A.et.al.   18034455
[6] “Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.”  Munton R.P.et.al.   17114649

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVSASRPEAL AAPVTTVATL VPHNATEPAS PGEGKEDAFS KLKQKFMNEL HKIPLPPWAL 
61:	IAIAIVAVLL VVTCCFCVCK KCLFKKKNKK KGKEKGGKNA INMKDVKDLG KTMKDQALKD 
121:	DDAETGLTDG EEKEEPKEEE KLGKLQYSLD YDFQNNQLLV GIIQAAELPA LDMGGTSDPY 
181:	VKVFLLPDKK KKFETKVHRK TLNPVFNEQF TFKVPYSELG GKTLVMAVYD FDRFSKHDII 
241:	GEFKVPMNTV DFGHVTEEWR DLQSAEKEEQ EKLGDICFSL RYVPTAGKLT VVILEAKNLK 
301:	KMDVGGLSDP YVKIHLMQNG KRLKKKKTTI KKNTLNPYYN ESFSFEVPFE QIQKVQVVVT 
361:	VLDYDKIGKN DAIGKVFVGY NSTGAELRHW SDMLANPRRP IAQWHTLQVE EEVDAMLAVK 
421:	K