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2.A.4.4.1
Heteromeric nuclear/ER Zn2+ uptake permease, Msc2/Zrg17 (Ellis et al., 2005).  Zrg17 is also called Meiotic sister-chromatid recombination-related protein or metal cation transporter Msc2p of 724 aas and 15 TMSs in a 7 + 2 + 6 TMS arrangement.  Only the last 6 TMSs are homologous to CDF transporters.

Accession Number:P53735
Protein Name:Zinc-regulated gene protein 17 aka ZRG17
Length:605
Molecular Weight:67461.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: P53735
eggNOG: fuNOG07207
HEGENOM: HBG202724
DIP: DIP-5210N
RefSeq: NP_014437.1   
Entrez Gene ID: 855775   
Pfam: PF01545   
KEGG: sce:YNR039C   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005515 F:protein binding
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (6)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.”  Philippsen P.et.al.   9169873
[2] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[3] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[4] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[5] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.”  Chi A.et.al.   17287358
[6] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	METPQMNAIQ EEDNLSPEVA FQTPKLNDSD ASSFSLSNMN AVGNVDGIPS QNRTFFASPR 
61:	PSSLFYSAKE GNNSSSSIIY NPSFTFGENA SSNANINEAA LMKGKGNEGR RQSLKYIPAP 
121:	KLVPPPPRTR SPVRGISPDA GSSKRSSMTL DSPFNFTTST LQPHQQTPPS SAASRTSFRK 
181:	GHRYKHSSVS MNFFQEPEVK IPLNIAKSLP IPDFNDLLSN LPWPKAYIQL SIAALQIFAC 
241:	LITFQVGHLY SWSNFITLSH FITYDIIGSL VIIFVENLSQ FQVWFTGTIT FPFGLNRIDV 
301:	LLSFALAVSL CFVGLDLLFH IIEEFIVLFV ESGSSLTNNH DHDEINEQIP HSHIANANDS 
361:	QNENITLWYS ILMINLVLST LSLYKTFYAN KYSNLKTKNP IITITYTAYL FIYPLLLDLL 
421:	SSISDYLATL VISSLILWHG LTIARWTSTV LLMGFSTTSL SNSALFNNND STDTTAHTQQ 
481:	VESKAAKEKP SVRPRSMSSL PIATKNTKIR KTGFLNSAGF TENPTTIKNM IKDQIERLSE 
541:	FKSRYILNYD DIVISKVNFT LYVVLIKITM KGGSDDDELM LRLAIDKCIQ TSIPTCETTI 
601:	DIDRI