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2.A.63.1.3
Multicomponent Na+:H+ antiporter, MnhABCDEFG

Accession Number:P60686
Protein Name:Na(+)/H(+) antiporter subunit D aka mnhD
Length:498
Molecular Weight:54756.00
Species:Staphylococcus aureus [1280]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Pfam: PF00361   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008137 F:NADH dehydrogenase (ubiquinone) activity
GO:0015386 F:potassium:hydrogen antiporter activity
GO:0042773 P:ATP synthesis coupled electron transport
GO:0015992 P:proton transport
GO:0006814 P:sodium ion transport

References (2)

[1] “A putative multisubunit Na+/H+ antiporter from Staphylococcus aureus.”  Hiramatsu T.et.al.   9852009
[2] “Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host.”  Swartz T.H.et.al.   17293423

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MIESNMLVLT LVIPVITAIL LVFIGKRPII KRYVALGGTL LTLVAAIINL ANVVKHGPIR 
61:	VELGSWKAPY SIVFVLDIFS ALLIITSIII TAIVILYSYQ TIGIERERYY YYFSVLFMLI 
121:	GIIGAFTTGD IFNLFVFFEV FLMSSYFLLV IGSTKIQLQE TIKYVLVNVV SSSFFVMGVA 
181:	ILYSVVGTLN LADISNKLAN LSAHDSGLVN IVFILFIFVF ATKAGVFPMF VWLPSAYYAP 
241:	PIPIIAFFGA LLTKVGVYAI ARTLSLFFSD NVSFSHYVIL FLALLTIIFG CVGAVAYANI 
301:	KKIILYNVMI AVGVILVGVA MMTESGMIGA IYYTLHDMLV KLALFLLIGI MIKITGTADL 
361:	RQFGGLIKRY PVLGWSFFIA ALSLAGIPPL SGFYGKFFIV QSTFERGFYL SGVIVLLSSL 
421:	VVLYSVIRIF LQGFFGQPKG YDLNNKVDVK YLTTIAIVAV VITVLYGLSA DYLYPMVKAG 
481:	AETFYNPSTY VKAVLGGK