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3.A.18.1.1
The nuclear mRNA Export Complex (mRNA-E also called TREX) (including the exon junction complex) [TAP+p15 interact as a complex with the nuclear pore to facilitate mRNA transport to the cytoplasm] (Nojimma et al. 2007; Cheng et al., 2006)

Accession Number:P61326
Protein Name:Protein mago nashi homolog aka MAGOH
Length:146
Molecular Weight:17164.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Nucleus1
Substrate mRNA

Cross database links:

Genevestigator: P61326
eggNOG: prNOG19338
HEGENOM: HBG319710
RefSeq: NP_002361.1   
Entrez Gene ID: 4116   
Pfam: PF02792   
OMIM: 602603  gene
KEGG: hsa:4116   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0035145 C:exon-exon junction complex
GO:0016607 C:nuclear speck
GO:0005681 C:spliceosomal complex
GO:0005515 F:protein binding
GO:0003723 F:RNA binding
GO:0006397 P:mRNA processing
GO:0051028 P:mRNA transport
GO:0000184 P:nuclear-transcribed mRNA catabolic process,...
GO:0006417 P:regulation of translation
GO:0008380 P:RNA splicing

References (21)

[1] “The mammalian homologue of mago nashi encodes a serum-inducible protein.”  Zhao X.F.et.al.   9479507
[2] “Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.”  Zhang Q.-H.et.al.   11042152
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “MAGOH interacts with a novel RNA-binding protein.”  Zhao X.F.et.al.   10662555
[7] “Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.”  Jurica M.S.et.al.   11991638
[8] “A novel mode of RBD-protein recognition in the Y14-Mago complex.”  Fribourg S.et.al.   12730685
[9] “Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex.”  Bono F.et.al.   14968132
[10] “Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.”  Gehring N.H.et.al.   16209946
[11] “The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.”  Ballut L.et.al.   16170325
[12] “Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.”  Tange T.O.et.al.   16314458
[13] “PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs.”  Diem M.D.et.al.   18026120
[14] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[15] “Disassembly of exon junction complexes by PYM.”  Gehring N.H.et.al.   19410547
[16] “Assembly and mobility of exon-exon junction complexes in living cells.”  Schmidt U.et.al.   19324961
[17] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[18] “Structure of the Y14-Magoh core of the exon junction complex.”  Lau C.K.et.al.   12781131
[19] “The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.”  Bono F.et.al.   16923391
[20] “Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.”  Andersen C.B.et.al.   16931718
[21] “Mechanism of ATP turnover inhibition in the EJC.”  Nielsen K.H.et.al.   19033377
Structure:
1P27   2HYI   2J0Q   2J0S   3EX7   2XB2     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL 
61:	KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR 
121:	VFYYLVQDLK CLVFSLIGLH FKIKPI