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3.A.1.21.2
The Fe3+-carboxymycobactin transporter, IrtAB (Rodriguez and Smith, 2006). IrtA contains an FAD-binding domain (Ryndak et al., 2010).

Accession Number:P63393
Protein Name:IrtB
Length:579
Molecular Weight:60954.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Fe3+-carboxymycobactin

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_215865.1    NP_335841.1   
Entrez Gene ID: 886834    924628   
Pfam: PF00005   
KEGG: mtc:MT1392    mtu:Rv1349   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MIRTWIALVP NDHRARLIGF ALLAFCSVVA RAVGTVLLVP LMAALFGEAP QRAWLWLGWL 
61:	SAATVAGWVL DAVTARIGIE LGFAVLNHTQ HDVADRLPVV RLDWFTAENT ATARQAIAAT 
121:	GPELVGLVVN LVTPLTSAIL LPAVIALALL PISWQLGVAA LAGVPLLLGA LWASAAFARR 
181:	ADTAADKANT ALTERIIEFA RTQQALRAAR RVEPARSLVG NALASQHTAT MRLLGMQIPG 
241:	QLLFSIASQL ALIVLAGTTA ALTITGTLTV PEAIALIVVM VRYLEPFTAV SELAPALEST 
301:	RATLGRIGSV LTAPVMVAGS GTWRDGAVVP RIEFDDVAFG YDGGSGPVLD GVSFCLQPGT 
361:	TTAIVGPSGC GKSTILALIA GLHQPTRGRV LIDGTDVATL DARAQQAVCS VVFQHPYLFH 
421:	GTIRDNVFAA DPGASDDQFA QAVRLARVDE LIARLPDGAN TIVGEAGSAL SGGERQRVSI 
481:	ARALLKAAPV LLVDEATSAL DAENEAAVVD ALAADPRSRT RVIVAHRLAS IRHADRVLFV 
541:	DDGRVVEDGS ISELLTAGGR FSQFWRQQHE AAEWQILAE