TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.5.26
The glutathione transporter, OppA (Dasgupta et al., 2010). OppA binds glutathione and the nanopeptide, bradykinin. Also regulates cytokine release, apoptosis and the innate immune response of macrophages infected with M. tuberculosis (Dasgupta et al., 2010).

Accession Number:P63395
Protein Name:Uncharacterized ABC transporter ATP-binding protein Rv1281c/MT1318
Length:612
Molecular Weight:65293.00
Species:Mycobacterium tuberculosis [1773]
Substrate Glutathione, Bradykinin

Cross database links:

HEGENOM: HBG758042
Entrez Gene ID: 886997    924755   
Pfam: PF00005    PF08352   
KEGG: mtc:MT1318    mtu:Rv1281c   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0015197 F:peptide transporter activity

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSPLLEVTDL AVTFRTDGDP VTAVRGISYR VEPGEVVAMV GESGSGKSAA AMAVVGLLPE 
61:	YAQVRGSVRL QGTELLGLAD NAMSRFRGKA IGTVFQDPMS ALTPVYTVGD QIAEAIEVHQ 
121:	PRVGKKAARR RAVELLDLVG ISQPQRRSRA FPHELSGGER QRVVIAIAIA NDPDLLICDE 
181:	PTTALDVTVQ AQILDVLKAA RDVTGAGVLI ITHDLGVVAE FADRALVMYA GRVVESAGVN 
241:	DLYRDRRMPY TVGLLGSVPR LDAAQGTRLV PIPGAPPSLA GLAPGCPFAP RCPLVIDECL 
301:	TAEPELLDVA TDHRAACIRT ELVTGRSAAD IYRVKTEARP AALGDASVVV RVRHLVKTYR 
361:	LAKGVVLRRA IGEVRAVDGI SLELRQGRTL GIVGESGSGK STTLHEILEL AAPQSGSIEV 
421:	LGTDVATLGT AERRSLRRDI QVVFQDPVAS LDPRLPVFDL IAEPLQANGF GKNETHARVA 
481:	ELLDIVGLRH GDASRYPAEF SGGQKQRIGI ARALALQPKI LALDEPVSAL DVSIQAGIIN 
541:	LLLDLQEQFG LSYLFVSHDL SVVKHLAHQV AVMLAGTVVE QGDSEEVFGN PKHEYTRRLL 
601:	GAVPQPDPAR RG