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3.A.1.5.26
The glutathione transporter, OppA (Dasgupta et al., 2010). OppA binds glutathione and the nanopeptide, bradykinin. Also regulates cytokine release, apoptosis and the innate immune response of macrophages infected with M. tuberculosis (Dasgupta et al., 2010).

Accession Number:P66771
Protein Name:Uncharacterized protein Rv1280c/MT1317
Length:591
Molecular Weight:63477.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate Glutathione, Bradykinin

Cross database links:

HEGENOM: HBG564824
Entrez Gene ID: 886985    924750   
Pfam: PF00496   
KEGG: mtc:MT1317    mtu:Rv1280c   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005215 F:transporter activity

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MADRGQRRGC APGIASALRA SFQGKSRPWT QTRYWAFALL TPLVVAMVLT GCSASGTQLE 
61:	LAPTADRRAA VGTTSDINQQ DPATLQDGGN LRLSLTDFPP NFNILHIDGN NAEVAAMMKA 
121:	TLPRAFIIGP DGSTTVDTNY FTSIELTRTA PQVVTYTINP EAVWSDGTPI TWRDIASQIH 
181:	AISGADKAFE IASSSGAERV ASVTRGVDDR QAVVTFAKPY AEWRGMFAGN GMLLPASMTA 
241:	TPEAFNKGQL DGPGPSAGPF VVSALDRTAQ RIVLTRNPRW WGARPRLDSI TYLVLDDAAR 
301:	LPALQNNTID ATGVGTLDQL TIAARTKGIS IRRAPGPSWY HFTLNGAPGS ILADKALRLA 
361:	IAKGIDRYTI ARVAQYGLTS DPVPLNNHVF VAGQDGYQDN SGVVAYNPEQ AKRELDALGW 
421:	RRSGAFREKD GRQLVIRDLF YDAQSTRQFA QIAQHTLAQI GVKLELQAKS GSGFFSDYVN 
481:	VGAFDIAQFG WVGDAFPLSS LTQIYASDGE SNFGKIGSPQ IDAAIERTLA ELDPGKARAL 
541:	ANQVDELIWA EGFSLPLTQS PGTVAVRSTL ANFGATGLAD LDYTAIGFMR R