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3.A.1.5.26
The glutathione transporter, OppA (Dasgupta et al., 2010). OppA binds glutathione and the nanopeptide, bradykinin. Also regulates cytokine release, apoptosis and the innate immune response of macrophages infected with M. tuberculosis (Dasgupta et al., 2010).

Accession Number:P66964
Protein Name:Putative peptide transport permease protein Rv1282c/MT1319
Length:291
Molecular Weight:31374.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Glutathione, Bradykinin

Cross database links:

HEGENOM: HBG729429
Entrez Gene ID: 886980    924753   
Pfam: PF00528   
KEGG: mtc:MT1319    mtu:Rv1282c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0015833 P:peptide transport
GO:0015031 P:protein transport

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTEFASRRTL VVRRFLRNRA AVASLAALLL LFVSAYALPP LLPYSYDDLD FNALLQPPGT 
61:	KHWLGTNALG QDLLAQTLRG MQKSMLIGVC VAVISTGIAA TVGAISGYFG GWRDRTLMWV 
121:	VDLLLVVPSF ILIAIVTPRT KNSANIMFLV LLLAGFGWMI SSRMVRGMTM SLREREFIRA 
181:	ARYMGVSSRR IIVGHVVPNV ASILIIDAAL NVAAAILAET GLSFLGFGIQ PPDVSLGTLI 
241:	ADGTASATAF PWVFLFPASI LVLILVCANL TGDGLRDALD PASRSLRRGV R