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3.A.1.5.26
The glutathione transporter, OppA (Dasgupta et al., 2010). OppA binds glutathione and the nanopeptide, bradykinin. Also regulates cytokine release, apoptosis and the innate immune response of macrophages infected with M. tuberculosis (Dasgupta et al., 2010).

Accession Number:P66966
Protein Name:Putative peptide transport permease protein Rv1283c/MT1320
Length:325
Molecular Weight:35083.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Glutathione, Bradykinin

Cross database links:

HEGENOM: HBG724229
Entrez Gene ID: 886981    924752   
Pfam: PF00528   
KEGG: mtc:MT1320    mtu:Rv1283c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0015833 P:peptide transport
GO:0015031 P:protein transport

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTRYLARRLL NYLVLLALAS FLTYCLTSLA FSPLESLMQR SPRPPQAVID AKAHDLGLDR 
61:	PILARYANWV SHAVRGDFGT TITGQPVGTE LGRRIGVSLR LLVVGSVFGT VAGVVIGAWG 
121:	AIRQYRLSDR VMTTLALLVL STPTFVVANL LILGALRVNW AVGIQLFDYT GETSPGVAGG 
181:	VWDRLGDRLQ HLILPSLTLA LAAAAGFSRY QRNAMLDVLG QDFIRTARAK GLTRRRALLK 
241:	HGLRTALIPM ATLFAYGVAG LVTGAVFVEK IFGWHGMGEW MVRGISTQDT NIVAAITVFS 
301:	GAVVLLAGLL SDVIYAALDP RVRVS