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3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Accession Number:P76142
Protein Name:LsrB(R)
Length:340
Molecular Weight:36685.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Periplasm1
Substrate Autoinducer-2

Cross database links:

Genevestigator: P76142
EchoBASE: EB3570
EcoGene: EG13809
eggNOG: COG1879
HEGENOM: HBG338994
RefSeq: AP_002137.1    NP_416033.1   
Entrez Gene ID: 945418   
BioCyc: EcoCyc:YNEA-MONOMER    ECOL168927:B1516-MONOMER   
KEGG: ecj:JW1509    eco:b1516   

Gene Ontology

GO:0042597 C:periplasmic space

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli.”  Xavier K.B.et.al.   15601708
[4] “Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli.”  Wang L.et.al.   15743955

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MTLHRFKKIA LLSALGIAAI SMNVQAAERI AFIPKLVGVG FFTSGGNGAQ QAGKELGVDV 
61:	TYDGPTEPSV SGQVQLINNF VNQGYNAIIV SAVSPDGLCP ALKRAMQRGV RVLTWDSDTK 
121:	PECRSYYINQ GTPAQLGGML VDMAARQVNK DKAKVAFFYS SPTVTDQNQW VKEAKAKIAK 
181:	EHPGWEIVTT QFGYNDATKS LQTAEGILKA YSDLDAIIAP DANALPAAAQ AAENLKNDKV 
241:	AIVGFSTPNV MRPYVERGTV KEFGLWDVVQ QGKISVYVAD ALLKKGSMKT GDKLDIKGVG 
301:	QVEVSPNSVQ GYDYEADGNG IVLLPERVIF NKENIGKYDF