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4.A.2.1.11
The FryABC putative transporter of unknown function.  FryA is a 3-domain multiphosphoryl transfer protein: EI-HPr-IIAFru (Reizer et al., 1995).

Accession Number:P77579
Protein Name:Fructose-like permease IIC component 1
Length:415
Molecular Weight:43966.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P77579
EchoBASE: EB3906
EcoGene: EG14154
eggNOG: COG1299
HEGENOM: HBG416920
RefSeq: AP_002986.1    NP_416887.1   
Entrez Gene ID: 949111   
Pfam: PF02378   
BioCyc: EcoCyc:MONOMER0-6    ECOL168927:B2386-MONOMER   
KEGG: ecj:JW2383    eco:b2386   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008982 F:protein-N(PI)-phosphohistidine-sugar phosph...
GO:0005351 F:sugar:hydrogen symporter activity
GO:0009401 P:phosphoenolpyruvate-dependent sugar phospho...

References (4)

[1] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAIKKRSATV VPGASGAAAA VKNPQASKTS FWGELPQHVM SGISRMVPTL IMGGVILAFS 
61:	QLIAYSWLKI PAEIGIMDAL NSGKFSGFDL SLLKFAWLSQ SFGGVLFGFA IPMFAAFVAN 
121:	SIGGKLAFPA GFIGGLMSTQ PTQLLNFDPS TMQWATSSPV PSTFIGALII SIVAGYLVKW 
181:	MNQKIQLPDF LLAFKTTFLL PILSAIFVML AMYYVITPFG GWINGGIRTV LTAAGEKGAL 
241:	MYAMGIAAAT AIDLGGPINK AAGFVAFSFT TDHVLPVTAR SIAIVIPPIG LGLATIIDRR 
301:	LTGKRLFNAQ LYPQGKTAMF LAFMGISEGA IPFALESPIT AIPSYMVGAI VGSTAAVWLG 
361:	AVQWFPESAI WAWPLVTNLG VYMAGIALGA VITALMVVFL RLMMFRKGKL LIDSL